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PMID: 15035025 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

SARS--beginning to understand a new virus.

Nature reviews. Microbiology ·Vol. 1 ·No. 3 ·2003-12-00 ·Pages 209-18

Stadler K, Masignani V, Eickmann M, Becker S, Abrignani S, Klenk HD, Rappuoli R

Abstract

The 114-day epidemic of the severe acute respiratory syndrome (SARS) swept 29 countries, affected a reported 8,098 people, left 774 patients dead and almost paralyzed the Asian economy. Aggressive quarantine measures, possibly aided by rising summer temperatures, successfully terminated the first eruption of SARS and provided at least a temporal break, which allows us to consolidate what we have learned so far and plan for the future. Here, we review the genomics of the SARS coronavirus (SARS-CoV), its phylogeny, antigenic structure, immune response and potential therapeutic interventions should the SARS epidemic flare up again.

MeSH Terms
Animals Genome, Viral Genomics Humans Phylogeny SARS Virus/classification,genetics,physiology Severe Acute Respiratory Syndrome/immunology,therapy,virology Viral Proteins/genetics,metabolism
Chemicals
Viral Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Stadler Konrad
IRIS, Chiron S.r.l., Via Fiorentina 1, 53100 Siena, Italy.
Masignani Vega
Eickmann Markus
Becker Stephan
Abrignani Sergio
Klenk Hans-Dieter
Rappuoli Rino
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Article Info
Journal
Nature reviews. Microbiology
Abbr.
Nat Rev Microbiol
ISSN
1740-1526
DOI
10.1038/nrmicro775
Published
2003-12-00
Pages
209-18
Language
English
Region
England
NLM ID
101190261
PMCID
PMC7097337
Subset
IM
External Links
PubMed source DOI: 10.1038/nrmicro775 PMC Full Text View journal details
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