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PMID: 12809601 Published · ppublish English Letter

mRNA cap-1 methyltransferase in the SARS genome.

Cell ·Vol. 113 ·No. 6 ·2003-06-13 ·Pages 701-2

von Grotthuss M, Wyrwicz LS, Rychlewski L

Abstract

The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy.

MeSH Terms
Carrier Proteins/genetics,metabolism Genome, Viral Methyltransferases/genetics,metabolism Models, Molecular Protein Structure, Tertiary/genetics RNA, Messenger/metabolism SARS Virus/enzymology,genetics Severe Acute Respiratory Syndrome/virology TNF Receptor-Associated Factor 3 Tumor Necrosis Factor Receptor-Associated Peptides and Proteins Viral Proteins/genetics,metabolism
Chemicals
Carrier Proteins RNA, Messenger TNF Receptor-Associated Factor 3 TRAF3 protein, human Tumor Necrosis Factor Receptor-Associated Peptides and Proteins Viral Proteins Methyltransferases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
von Grotthuss Marcin
Wyrwicz Lucjan S
Rychlewski Leszek
References (12)
12 references, click to expand
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
0092-8674
DOI
10.1016/s0092-8674(03)00424-0
Published
2003-06-13
Pages
701-2
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC7126025
Subset
IM
External Links
PubMed source DOI: 10.1016/s0092-8674(03)00424-0 PMC Full Text View journal details
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