Abstract
In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.
MeSH Terms
Amino Acid Sequence
Conserved Sequence
Coronavirus/classification,genetics
Coronavirus M Proteins
Coronavirus Nucleocapsid Proteins
DNA, Complementary
Endopeptidases/chemistry,genetics
Genome, Viral
Humans
Membrane Glycoproteins/chemistry,genetics
Molecular Sequence Data
Nucleocapsid Proteins/chemistry,genetics
Open Reading Frames
Phylogeny
Polyproteins/chemistry,genetics
RNA, Messenger/genetics,metabolism
RNA, Viral/genetics
RNA-Dependent RNA Polymerase/chemistry,genetics
Regulatory Sequences, Nucleic Acid
SARS Virus/chemistry,classification,genetics,isolation & purification
Sequence Analysis, DNA
Severe Acute Respiratory Syndrome/virology
Spike Glycoprotein, Coronavirus
Transcription, Genetic
Viral Envelope Proteins/chemistry,genetics
Viral Matrix Proteins/chemistry,genetics
Viral Proteins/chemistry,genetics
Chemicals
Coronavirus M Proteins
Coronavirus Nucleocapsid Proteins
DNA, Complementary
M protein, SARS-CoV
Membrane Glycoproteins
Nucleocapsid Proteins
Polyproteins
RNA, Messenger
RNA, Viral
Spike Glycoprotein, Coronavirus
Viral Envelope Proteins
Viral Matrix Proteins
Viral Proteins
RNA-Dependent RNA Polymerase
Endopeptidases
Authors & Affiliations
35 authors, click to expand affiliations / ORCID
Rota Paul A
National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. prota@cdc.gov
Oberste M Steven
Monroe Stephan S
Nix W Allan
Campagnoli Ray
Icenogle Joseph P
Peñaranda Silvia
Bankamp Bettina
Maher Kaija
Chen Min-Hsin
Tong Suxiong
Tamin Azaibi
Lowe Luis
Frace Michael
DeRisi Joseph L
Chen Qi
Wang David
Erdman Dean D
Peret Teresa C T
Burns Cara
Ksiazek Thomas G
Rollin Pierre E
Sanchez Anthony
Liffick Stephanie
Holloway Brian
Limor Josef
McCaustland Karen
Olsen-Rasmussen Melissa
Fouchier Ron
Günther Stephan
Osterhaus Albert D M E
Drosten Christian
Pallansch Mark A
Anderson Larry J
Bellini William J
