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PMID: 12040123 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis.

Microbiology and molecular biology reviews : MMBR ·Vol. 66 ·No. 2 ·2002-06-00 ·Pages 179-202

Sullivan CS, Pipas JM

Abstract

Simian virus 40 (SV40) is a small DNA tumor virus that has been extensively characterized due to its relatively simple genetic organization and the ease with which its genome is manipulated. The large and small tumor antigens (T antigens) are the major regulatory proteins encoded by SV40. Large T antigen is responsible for both viral and cellular transcriptional regulation, virion assembly, viral DNA replication, and alteration of the cell cycle. Deciphering how a single protein can perform such numerous and diverse functions has remained elusive. Recently it was established that the SV40 T antigens, including large T antigen, are molecular chaperones, each with a functioning DnaJ domain. The molecular chaperones were originally identified as bacterial genes essential for bacteriophage growth and have since been shown to be conserved in eukaryotes, participating in an array of both viral and cellular processes. This review discusses the mechanisms of DnaJ/Hsc70 interactions and how they are used by T antigen to control viral replication and tumorigenesis. The use of the DnaJ/Hsc70 system by SV40 and other viruses suggests an important role for these molecular chaperones in the regulation of the mammalian cell cycle and sheds light on the enigmatic SV40 T antigen-a most amazing molecule.

MeSH Terms
Amino Acid Sequence Animals Antigens, Polyomavirus Transforming/genetics,physiology Cell Transformation, Neoplastic Models, Biological Models, Molecular Molecular Chaperones/genetics,physiology Molecular Sequence Data Polyomavirus Infections/etiology Retinoblastoma Protein/physiology Simian virus 40/genetics,pathogenicity,physiology Tumor Suppressor Protein p53/physiology Tumor Virus Infections/etiology Virus Replication/physiology
Chemicals
Antigens, Polyomavirus Transforming Molecular Chaperones Retinoblastoma Protein Tumor Suppressor Protein p53
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sullivan Christopher S
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Pipas James M
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1092-2172
DOI
10.1128/MMBR.66.2.179-202.2002
Published
2002-06-00
Pages
179-202
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC120785
Subset
IM
Grants
NCI NIH HHS · R01 CA040586 · United States
NCI NIH HHS · CA40586 · United States
External Links
PubMed source DOI: 10.1128/MMBR.66.2.179-202.2002 PMC Full Text View journal details
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