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PMID: 1406933 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Effects of an Rb mutation in the mouse.

Nature ·Vol. 359 ·No. 6393 ·1992-09-24 ·Pages 295-300

Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA

Abstract

The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die between days 14 and 15 of gestation, exhibiting neuronal cell death and defective erythropoiesis.

Related Genes

MeSH Terms

Amino Acid Sequence Animals Base Sequence Cell Death Erythropoiesis/genetics Eye Neoplasms/genetics Genes, Retinoblastoma Heterozygote Homozygote Humans Liver/embryology Mice Mice, Mutant Strains/genetics Molecular Sequence Data Mutation Neurons/cytology,physiology Phenotype Restriction Mapping Retinoblastoma/genetics

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Jacks T

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

Fazeli A

Schmitt E M

Bronson R T

Goodell M A

Weinberg R A

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/359295a0

Published

1992-09-24

Pages

295-300

Language

English

Region

England

NLM ID

0410462

Subset

Corrections

CommentIn

PMID: 1406928

External Links

PubMed source DOI: 10.1038/359295a0 View journal details

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Effects of an Rb mutation in the mouse.

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