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PMID: 6086957 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human polyomavirus JC virus genome.

Journal of virology ·Vol. 51 ·No. 2 ·1984-08-00 ·Pages 458-69

Frisque RJ, Bream GL, Cannella MT

Abstract

The complete DNA sequence of the human JC virus, which was found to consist of 5,130 nucleotide pairs, is presented. The amino acid sequence of six proteins could be deduced: the early, nonstructural proteins, large T and small t antigens; the late capsid proteins, VP1, VP2, and VP3; and the agnogene product encoded within the late leader sequence, called the agnoprotein in simian virus 40. The extent of homology between JC virus DNA and the genomes of simian virus 40 (69%) and BK virus (75%) confirmed the close evolutionary relationship of these three polyomaviruses. The sequences showing the greatest divergence in these viral DNAs occurred within the tandem repeats located to the late side of the replication origins.

MeSH Terms
Amino Acid Sequence Antigens, Polyomavirus Transforming Base Sequence Cells, Cultured DNA Restriction Enzymes DNA, Viral/genetics Female Fetus Genes, Viral Humans JC Virus/genetics Neuroglia Polyomavirus/genetics Pregnancy Protein Kinases/immunology RNA, Messenger/genetics Viral Proteins/immunology Viral Regulatory and Accessory Proteins
Chemicals
Antigens, Polyomavirus Transforming DNA, Viral RNA, Messenger Viral Proteins Viral Regulatory and Accessory Proteins agnoprotein, polyomavirus Protein Kinases DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Frisque R J
Bream G L
Cannella M T
References (73)
73 references, click to expand
  1. Topography of simian virus 40 A protein-DNA complexes: arrangement of pentanucleotide interaction sites at the origin of replication.
    J Virol. 1983 Apr;46(1):143-50 PMID: 6298451
  2. Nucleotide sequence of the region encompassing the JC virus origin of DNA replication.
    J Virol. 1983 Apr;46(1):170-6 PMID: 6298454
  3. Definition of the simian virus 40 early promoter region and demonstration of a host range bias in the enhancement effect of the simian virus 40 72-base-pair repeat.
    Proc Natl Acad Sci U S A. 1983 Feb;80(3):721-5 PMID: 6298771
  4. Regulatory sequences and virus-cell interactions of JC virus.
    Prog Clin Biol Res. 1983;105:41-59 PMID: 6304771
  5. Identification of a promoter component involved in positioning the 5' termini of simian virus 40 early mRNAs.
    Proc Natl Acad Sci U S A. 1981 Jan;78(1):100-4 PMID: 6264425
  6. Use of whole-cell fixation to visualize replicating and maturing simian virus 40: identification of new viral gene product.
    Proc Natl Acad Sci U S A. 1981 Oct;78(10):6081-5 PMID: 6273846
  7. A region of the polyoma virus genome between the replication origin and late protein coding sequences is required in cis for both early gene expression and viral DNA replication.
    Nucleic Acids Res. 1981 Dec 11;9(23):6231-50 PMID: 6275353
  8. A small segment of polyoma virus DNA enhances the expression of a cloned beta-globin gene over a distance of 1400 base pairs.
    Nucleic Acids Res. 1981 Dec 11;9(23):6251-64 PMID: 6275354
  9. DNA sequences necessary for transcription of the rabbit beta-globin gene in vivo.
    Nature. 1982 Jan 14;295(5845):120-6 PMID: 6276753
  10. Simian virus 40 tumor antigen: isolation of the origin-specific DNA-binding domain.
    J Virol. 1983 Jul;47(1):106-14 PMID: 6306267
  11. Sequence repeats in a polyoma virus DNA region important for gene expression.
    J Virol. 1983 Jul;47(1):233-7 PMID: 6306275
  12. Suppression of a VP1 mutant of simian virus 40 by missense mutations in serine codons of the viral agnogene.
    J Virol. 1983 Nov;48(2):405-9 PMID: 6312098
  13. The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter.
    Cell. 1983 Nov;35(1):79-87 PMID: 6313230
  14. BK viral enhancer element and a human cellular homolog.
    Science. 1983 Nov 18;222(4625):749-55 PMID: 6314501
  15. Territorial limits and functional anatomy of the simian virus 40 replication origin.
    Proc Natl Acad Sci U S A. 1982 Jan;79(2):381-5 PMID: 6281769
  16. Transcriptional control signals of a eukaryotic protein-coding gene.
    Science. 1982 Jul 23;217(4557):316-24 PMID: 6283634
  17. Change of DNA near the origin of replication enhances the transforming capacity of human papovavirus BK.
    J Virol. 1982 Jun;42(3):978-85 PMID: 6285007
  18. Discrete regions of simian virus 40 large T antigen are required for nonspecific and viral origin-specific DNA binding.
    J Virol. 1982 Jul;43(1):73-82 PMID: 6287017
  19. Selective extraction of polyoma DNA from infected mouse cell cultures.
    J Mol Biol. 1967 Jun 14;26(2):365-9 PMID: 4291934
  20. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy.
    Lancet. 1971 Jun 19;1(7712):1257-60 PMID: 4104715
  21. Structure and function of the polypeptides in simian virus 40. I. Existence of subviral deoxynucleoprotein complexes.
    J Virol. 1972 Jun;9(6):923-9 PMID: 4113888
  22. Prevalence of antibodies in human sera against JC virus, an isolate from a case of progressive multifocal leukoencephalopathy.
    J Infect Dis. 1973 Apr;127(4):467-70 PMID: 4571704
  23. Human papovavirus (JC): induction of brain tumors in hamsters.
    Science. 1973 Aug 17;181(4100):674-6 PMID: 4353360
  24. Isolation of papovavirus from brain tumor and urine of a patient with Wiskott-Aldrich syndrome.
    J Natl Cancer Inst. 1974 Nov;53(5):1205-7 PMID: 4214938
  25. Sequence at the 3' end of globin mRNA shows homology with immunoglobulin light chain mRNA.
    Nature. 1974 Nov 29;252(5482):359-62 PMID: 4139664
  26. Construction and analysis of viable deletion mutants of simian virus 40.
    J Virol. 1976 May;18(2):664-71 PMID: 178902
  27. JC Papovavirus in progressive multifocal leukoencephalopathy.
    J Infect Dis. 1976 Jun;133(6):686-90 PMID: 778304
  28. Nucleotide sequence of a fragment of SV40 DNA that contains the origin of DNA replication and specifies the 5' ends of "early" and "late" viral RNA. III. Construction of the total sequence of EcoRII-G fragment of SV40 DNA.
    J Biol Chem. 1977 Jan 10;252(1):355-67 PMID: 188810
  29. Common structural antigen of papovaviruses of the simian virus 40-polyoma subgroup.
    J Virol. 1977 Jan;21(1):179-86 PMID: 64625
  30. Differential neurooncogenicity of strains of JC virus, a human polyoma virus, in newborn Syrian hamsters.
    Cancer Res. 1977 Mar;37(3):718-20 PMID: 189911
  31. JC virus, a human polyomavirus associated with progressive multifocal leukoencephalopathy: additional biological characteristics and antigenic relationships.
    Infect Immun. 1977 Feb;15(2):656-62 PMID: 191404
  32. Structure of a large segment of the genome of simian virus 40 that does not encode known proteins.
    Proc Natl Acad Sci U S A. 1977 Mar;74(3):827-31 PMID: 191835
  33. Nucleotide sequences of DNA encoding the 3' ends of SV40 mRNA. I. The sequence of the DNA fragment Hi-DII,III-G.
    J Biol Chem. 1978 Mar 10;253(5):1606-12 PMID: 203596
  34. T antigen of BK papovavirus in infected and transformed cells.
    J Virol. 1978 Mar;25(3):871-7 PMID: 205676
  35. Complete nucleotide sequence of SV40 DNA.
    Nature. 1978 May 11;273(5658):113-20 PMID: 205802
  36. The genome of simian virus 40.
    Science. 1978 May 5;200(4341):494-502 PMID: 205947
  37. Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus).
    Science. 1978 Sep 29;201(4362):1246-9 PMID: 211583
  38. Translation of polyoma virus T antigens in vitro.
    Proc Natl Acad Sci U S A. 1978 Dec;75(12):5917-21 PMID: 216001
  39. T antigen is bound to a host protein in SV40-transformed cells.
    Nature. 1979 Mar 15;278(5701):261-3 PMID: 218111
  40. The colinear alignment of the genomes of papovaviruses JC, BK, and SV40.
    Virology. 1979 Jul 30;96(2):576-87 PMID: 223318
  41. Functional similarity between the early antigens of simian virus 40 and human papovavirus BK.
    J Virol. 1979 Apr;30(1):141-7 PMID: 225512
  42. Simian virus 40 early mRNA's. I. Genomic localization of 3' and 5' termini and two major splices in mRNA from transformed and lytically infected cells.
    J Virol. 1979 Apr;30(1):279-96 PMID: 90157
  43. Helper function for adenovirus replication in monkey cells by BK human papovavirus.
    Virology. 1979 Oct 15;98(1):279-82 PMID: 225869
  44. Protein-DNA interactions at the origin of simian virus 40 DNA replication.
    Cold Spring Harb Symp Quant Biol. 1979;43 Pt 2:655-61 PMID: 226310
  45. Infectivity of the DNA from four isolates of JC virus.
    J Virol. 1979 Nov;32(2):476-82 PMID: 228071
  46. BK virus DNA: complete nucleotide sequence of a human tumor virus.
    Science. 1979 Oct 26;206(4417):456-62 PMID: 228391
  47. Viable deletion mutant of human papovavirus BK that induces insulinomas in hamsters.
    J Virol. 1979 Dec;32(3):934-42 PMID: 229273
  48. The genome of human papovavirus BKV.
    Cell. 1979 Dec;18(4):963-77 PMID: 229976
  49. Mutational analysis of the simian virus 40 replicon: pseudorevertants of mutants with a defective replication origin.
    Proc Natl Acad Sci U S A. 1979 Dec;76(12):6128-31 PMID: 230499
  50. The ovalbumin gene-sequence of putative control regions.
    Nucleic Acids Res. 1980 Jan 11;8(1):127-42 PMID: 6243777
  51. Experimental glioma in primates: a computed tomography model.
    J Comput Assist Tomogr. 1980 Jun;4(3):285-90 PMID: 6246149
  52. Sequencing end-labeled DNA with base-specific chemical cleavages.
    Methods Enzymol. 1980;65(1):499-560 PMID: 6246368
  53. Expression of polyoma early functions in mouse embryonal carcinoma cells depends on sequence rearrangements in the beginning of the late region.
    Cell. 1980 Jun;20(2):393-9 PMID: 6248241
  54. Mapping of SV40 DNA replication origin region binding sites for the SV40 T antigen by protection against exonuclease III digestion.
    Cell. 1980 Jun;20(2):411-22 PMID: 6248243
  55. Transformation of primary hamster brain cells with JC virus and its DNA.
    J Virol. 1980 Jul;35(1):265-9 PMID: 6251275
  56. Characterization of tau antigens isolated from uninfected and simian virus 40-infected monkey cells and papovavirus-transformed cells.
    J Virol. 1980 Nov;36(2):519-25 PMID: 6253675
  57. Expression of early genes of origin-defective mutants of simian virus 40.
    Proc Natl Acad Sci U S A. 1980 Jul;77(7):3898-902 PMID: 6254000
  58. Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen.
    Proc Natl Acad Sci U S A. 1980 Oct;77(10):5706-10 PMID: 6255460
  59. Construction and analysis of simian virus 40 origins defective in tumor antigen binding and DNA replication.
    Proc Natl Acad Sci U S A. 1980 Nov;77(11):6491-5 PMID: 6256739
  60. In vivo sequence requirements of the SV40 early promotor region.
    Nature. 1981 Mar 26;290(5804):304-10 PMID: 6259538
  61. Polyoma DNA sequences involved in control of viral gene expression in murine embryonal carcinoma cells.
    Nature. 1981 Apr 23;290(5808):720-2 PMID: 6261151
  62. Mutation near the polyoma DNA replication origin permits productive infection of F9 embryonal carcinoma cells.
    Cell. 1981 Mar;23(3):809-14 PMID: 6261957
  63. Identification of the SV40 agnogene product: a DNA binding protein.
    Nature. 1981 May 28;291(5813):346-9 PMID: 6262654
  64. Simian virus 40 tandem repeated sequences as an element of the early promoter.
    Proc Natl Acad Sci U S A. 1981 Feb;78(2):943-7 PMID: 6262784
  65. DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus.
    Proc Natl Acad Sci U S A. 1981 Mar;78(3):1411-5 PMID: 6262796
  66. Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus.
    Nature. 1982 Feb 18;295(5850):568-72 PMID: 6276775
  67. Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system.
    Cell. 1981 Dec;27(2 Pt 1):279-88 PMID: 6277501
  68. Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences.
    Cell. 1981 Dec;27(2 Pt 1):299-308 PMID: 6277502
  69. Comparison of infectious JC virus DNAs cloned from human brain.
    J Virol. 1983 Jan;45(1):299-308 PMID: 6296438
  70. Mutants deleted in the agnogene of simian virus 40 define a new complementation group.
    J Virol. 1983 Jan;45(1):36-46 PMID: 6296443
  71. Genomic structure of human polyoma virus JC: nucleotide sequence of the region containing replication origin and small-T-antigen gene.
    J Virol. 1983 Jan;45(1):73-9 PMID: 6296460
  72. Multiple point mutations affecting the simian virus 40 enhancer.
    Science. 1983 Feb 11;219(4585):626-31 PMID: 6297005
  73. The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements.
    Cell. 1983 Feb;32(2):503-14 PMID: 6297796
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.51.2.458-469.1984
Published
1984-08-00
Pages
458-69
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254460
Subset
IM
Databases
GENBANK
J02226, J02227, V01118
External Links
PubMed source DOI: 10.1128/JVI.51.2.458-469.1984 PMC Full Text View journal details
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