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PMID: 11805343 Published · ppublish English Journal Article

Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 99 ·No. 2 ·2002-01-22 ·Pages 1041-6

Renger JJ, Hartman KN, Tsuchimoto Y, Yokoi M, Nakanishi S, Hensch TK

Abstract

Synaptic depression is thought to underlie the loss of cortical responsiveness to an eye deprived of vision. Here, we establish a fundamental role for type 2 metabotropic glutamate receptors (mGluR2) in long-term depression (LTD) of synaptic transmission within primary visual cortex. Direct mGluR2 activation by (2S,2'R,3'R-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV) persistently depressed layer 2/3 field potentials in slices of mouse binocular zone when stimulated concomitantly. Chemical LTD was independent of N-methyl-d-aspartate (NMDA) receptors but occluded conventional LTD by low-frequency stimulation, indicating shared downstream events. Antagonists or targeted disruption of mGluR2 conversely prevented LTD induction by electrical low-frequency stimulation to layer 4. In contrast, Schaeffer collateral synapses did not exhibit chemical LTD, revealing hippocampal area CA1, naturally devoid of mGluR2, to be an inappropriate model for neocortical plasticity. Moreover, monocular deprivation remained effective in mice lacking mGluR2, and receptor expression levels were unchanged during the critical period in wild-type mice, indicating that experience-dependent plasticity is independent of LTD induction in visual cortex. Short-term depression that was unaffected by mGluR2 deletion may better reflect circuit refinement in vivo.

MeSH Terms
Animals Immunohistochemistry In Vitro Techniques Mice Mice, Knockout Models, Neurological Neuronal Plasticity/physiology Receptors, Metabotropic Glutamate/deficiency,genetics,physiology Synaptic Transmission/physiology Visual Cortex/anatomy & histology,growth & development,physiology
Chemicals
Receptors, Metabotropic Glutamate metabotropic glutamate receptor 2
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Renger John J
Laboratory for Neuronal Circuit Development, Institute of Physical and Chemical Research (RIKEN), Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
Hartman Kenichi N
Tsuchimoto Yoshiko
Yokoi Mineto
Nakanishi Shigetada
Hensch Takao K
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.022618799
Published
2002-01-22
Pages
1041-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC117426
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.022618799 PMC Full Text View journal details
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