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PMID: 8097320 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Dependence of long-term depression on postsynaptic metabotropic glutamate receptors in visual cortex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 8 ·1993-04-15 ·Pages 3650-4

Kato N

Abstract

Long-term depression (LTD) is held relevant to memory and learning. Its induction is known to require postsynaptic calcium increases. However, the source of these calcium increases remains unclear. In visual cortex slices, LTD was induced by tetanization after blockade of N-methyl-D-aspartate (NMDA) and non-NMDA ionotropic glutamate receptors. LTD induced under this condition was prevented by an intracellular injection of each of the following drugs into the postsynaptic neuron: (i) guanosine 5'-[beta-thio]diphosphate, which competitively inhibits the binding of GTP to GTP-binding regulatory proteins; (ii) heparin, which antagonizes 1,4,5-inositol triphosphate binding; and (iii) calcium chelators. Moreover, LTD was induced without tetanization by applying quisqualate (10 microM), a metabotropic glutamate receptor agonist, but not another agonist, trans-aminocyclopentane-1,3-dicarboxylic acid (10 microM). Together, these results suggest that activation of 1,4,5-inositol trisphosphate-linked subtypes of metabotropic glutamate receptor is responsible for the increase in postsynaptic calcium concentration, which results in homosynaptic LTD.

MeSH Terms
2-Amino-5-phosphonovalerate/pharmacology 6-Cyano-7-nitroquinoxaline-2,3-dione Amino Acids/pharmacology Animals Anticonvulsants/pharmacology Bicuculline/pharmacology Cyclopentanes/pharmacology Evoked Potentials/drug effects Guanosine Diphosphate/analogs & derivatives,pharmacology Heparin/pharmacology In Vitro Techniques Kinetics Neuronal Plasticity/drug effects,physiology Neurons/drug effects,physiology Quinoxalines/pharmacology Quisqualic Acid/pharmacology Rats Receptors, Glutamate/drug effects,physiology Synapses/drug effects,physiology Thionucleotides/pharmacology Visual Cortex/drug effects,physiology gamma-Aminobutyric Acid/physiology
Chemicals
Amino Acids Anticonvulsants Cyclopentanes Quinoxalines Receptors, Glutamate Thionucleotides Guanosine Diphosphate gamma-Aminobutyric Acid 3-aminocyclopentane-1-carboxylic acid 6-Cyano-7-nitroquinoxaline-2,3-dione guanosine 5'-O-(2-thiodiphosphate) 2-Amino-5-phosphonovalerate Quisqualic Acid Heparin 2-amino-7-phosphonoheptanoic acid Bicuculline
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kato N
Department of Integrative Brain Science, Faculty of Medicine, Kyoto University, Japan.
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.8.3650
Published
1993-04-15
Pages
3650-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC46359
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.90.8.3650 PMC Full Text View journal details
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