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PMID: 8223907 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus.

European journal of pharmacology ·Vol. 239 ·No. 1-3 ·1993-08-03 ·Pages 265-6

Bashir ZI, Jane DE, Sunter DC, Watkins JC, Collingridge GL

Abstract

Long-term depression of synaptic transmission was induced following the prior induction of long-term potentiation in the CA1 region of rat hippocampal slices. We show that the induction of this form of synaptic depression can be prevented by (+)-alpha-methyl-4-carboxyphenylglycine, a selective antagonist of metabotropic glutamate receptors.

MeSH Terms

Animals Benzoates/pharmacology Electric Stimulation Glycine/analogs & derivatives,pharmacology Hippocampus/drug effects,physiology In Vitro Techniques Rats Receptors, Metabotropic Glutamate/antagonists & inhibitors,physiology Synaptic Transmission/drug effects

Chemicals

Benzoates Receptors, Metabotropic Glutamate alpha-methyl-4-carboxyphenylglycine Glycine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Bashir Z I

Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, UK.

Jane D E

Sunter D C

Watkins J C

Collingridge G L

Article Info

Journal

European journal of pharmacology

Abbr.

Eur J Pharmacol

ISSN

0014-2999

DOI

10.1016/0014-2999(93)91009-c

Published

1993-08-03

Pages

265-6

Language

English

Region

Netherlands

NLM ID

1254354

Subset

External Links

PubMed source DOI: 10.1016/0014-2999(93)91009-c View journal details

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Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus.

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