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PMID: 9822384 Published · ppublish English Journal Article

Local GABA circuit control of experience-dependent plasticity in developing visual cortex.

Science (New York, N.Y.) ·Vol. 282 ·No. 5393 ·1998-11-20 ·Pages 1504-8

Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SF

Abstract

Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model. Gene-targeted disruption of one isoform of glutamic acid decarboxylase prevented the competitive loss of responsiveness to an eye briefly deprived of vision, without affecting cooperative mechanisms of synapse modification in vitro. Selective, use-dependent enhancement of fast intracortical inhibitory transmission with benzodiazepines restored plasticity in vivo, rescuing the genetic defect. Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development.

MeSH Terms
Animals Diazepam/pharmacology GABA Modulators/pharmacology Gene Targeting Glutamate Decarboxylase/genetics,metabolism Interneurons/physiology Long-Term Potentiation Mice Mice, Inbred C57BL Mice, Knockout Neuronal Plasticity/drug effects Photic Stimulation Receptors, GABA-A/metabolism Synaptic Transmission Visual Cortex/cytology,metabolism,physiology Visual Pathways gamma-Aminobutyric Acid/metabolism
Chemicals
GABA Modulators Receptors, GABA-A gamma-Aminobutyric Acid Glutamate Decarboxylase Diazepam
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Hensch T K
Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. hensch@postman.riken.go.jp
Fagiolini M
Mataga N
Stryker M P
Baekkeskov S
Kash S F
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.282.5393.1504
Email
hensch@postman.riken.go.jp
Published
1998-11-20
Pages
1504-8
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2851625
Subset
IM
Grants
NEI NIH HHS · R37 EY002874 · United States
NEI NIH HHS · R37 EY002874-20 · United States
External Links
PubMed source DOI: 10.1126/science.282.5393.1504 PMC Full Text View journal details
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