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PMID: 10559388 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Dopamine receptors and groups I and II mGluRs cooperate for long-term depression induction in rat prefrontal cortex through converging postsynaptic activation of MAP kinases.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 19 ·No. 22 ·1999-11-15 ·Pages 9788-802

Otani S, Auclair N, Desce JM, Roisin MP, Crépel F

Abstract

Tetanic stimuli to layer I-II afferents in rat prefrontal cortex induced long-term depression (LTD) of layer I-II to layer V pyramidal neuron glutamatergic synapses when tetani were coupled to bath application of dopamine. This LTD was blocked by the following metabotropic glutamate receptor (mGluR) antagonists coapplied with dopamine: (S)-alpha-methyl-4-carboxyphenylglycine (MCPG; group I and II antagonist), (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA; group I antagonist), or (RS)-alpha-methylserine-O-phosphate monophenyl ester (MSOPPE; group II antagonist). This suggests that the dopamine-facilitated LTD requires synaptic activation of groups I and II mGluRs during tetanus. LTD could also be induced by coupling tetani to bath application of groups I and II mGluR agonist (1S, 3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). In the next series of experiments, coapplication of dopamine and 1S,3R-ACPD, but not application of either drug alone, consistently induced LTD without tetani or even single test stimuli during drug application, suggesting that coactivation of dopamine receptors and the mGluRs is sufficient for LTD induction. Immunoblot analyses with anti-active mitogen-activated protein kinases (MAP-Ks) revealed that D1 receptors, D2 receptors, group I mGluRs, and group II mGluRs all contribute to MAP-K activation in prefrontal cortex, and that combined activation of dopamine receptors and mGluRs synergistically or additively activate MAP-Ks. Consistently, LTD by dopamine + 1S, 3R-ACPD coapplication, as well as the two other forms of LTD (LTD by dopamine + tetani and LTD by 1S,3R-ACPD + tetani), was blocked by bath application of MAP-K kinase inhibitor PD98059. LTD by dopamine + 1S,3R-ACPD coapplication was also blocked by postsynaptic injection of synthetic MAP-K substrate peptide. Our results suggest that dopamine receptors and groups I and II mGluRs cooperate to induce LTD through converging postsynaptic activation of MAP-Ks.

MeSH Terms
Animals Benzoates/pharmacology Cycloleucine/analogs & derivatives,pharmacology Dopamine/pharmacology Electric Stimulation Enzyme Activation Excitatory Amino Acid Agonists/pharmacology Excitatory Amino Acid Antagonists/pharmacology Glycine/analogs & derivatives,pharmacology In Vitro Techniques Indans/pharmacology Kinetics Male Mitogen-Activated Protein Kinases/metabolism Models, Neurological Neuronal Plasticity/drug effects,physiology Phosphoserine/analogs & derivatives,pharmacology Prefrontal Cortex/drug effects,physiology Rats Rats, Sprague-Dawley Receptors, Dopamine/physiology Receptors, Metabotropic Glutamate/agonists,antagonists & inhibitors,physiology
Chemicals
1-aminoindan-1,5-dicarboxylic acid Benzoates Excitatory Amino Acid Agonists Excitatory Amino Acid Antagonists Indans Receptors, Dopamine Receptors, Metabotropic Glutamate methylserine phosphate Cycloleucine 1-amino-1,3-dicarboxycyclopentane alpha-methyl-4-carboxyphenylglycine Phosphoserine Mitogen-Activated Protein Kinases Glycine Dopamine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Otani S
Laboratoire de Neurobiologie et Neuropharmacologie du Développement, Institut des Neurosciences, Université de Paris VI, 75005 Paris, France. satoru.otani@snv.jusseiu.fr
Auclair N
Desce J M
Roisin M P
Crépel F
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
Email
satoru.otani@snv.jusseiu.fr
Published
1999-11-15
Pages
9788-802
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6782965
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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