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PMID: 9096402 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 7 ·1997-04-01 ·Pages 3380-3

Kirkwood A, Silva A, Bear MF

Abstract

Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking alpha-calcium/calmodulin-dependent protein kinase II (alphaCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in alphaCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age.

MeSH Terms
Aging/physiology Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases/genetics Cerebral Cortex/enzymology,physiology Long-Term Potentiation Mice Mice, Mutant Strains Neuronal Plasticity
Chemicals
Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kirkwood A
Department of Neuroscience, Brown University, Providence, RI 02912, USA.
Silva A
Bear M F
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.94.7.3380
Published
1997-04-01
Pages
3380-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC20378
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.94.7.3380 PMC Full Text View journal details
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