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PMID: 10818003 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.

Science (New York, N.Y.) ·Vol. 288 ·No. 5469 ·2000-05-19 ·Pages 1254-7

Huber KM, Kayser MS, Bear MF

Abstract

A hippocampal pyramidal neuron receives more than 10(4) excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse can be regulated on the basis of activity. Here, local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.

MeSH Terms

Amino Acids/pharmacology Animals Anisomycin/pharmacology Dendrites/drug effects,metabolism Electric Stimulation Excitatory Amino Acid Antagonists/pharmacology Hippocampus/metabolism,physiology Methoxyhydroxyphenylglycol/analogs & derivatives,pharmacology Nerve Tissue Proteins/antagonists & inhibitors,biosynthesis,genetics Neural Inhibition/drug effects,physiology Protein Biosynthesis/drug effects Protein Synthesis Inhibitors/pharmacology RNA, Messenger/metabolism Rats Receptors, Metabotropic Glutamate/physiology Synaptic Transmission/drug effects,physiology Xanthenes/pharmacology

Chemicals

Amino Acids Excitatory Amino Acid Antagonists LY 341495 Nerve Tissue Proteins Protein Synthesis Inhibitors RNA, Messenger Receptors, Metabotropic Glutamate Xanthenes Methoxyhydroxyphenylglycol Anisomycin 3,4-dihydroxyphenylglycol

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Huber K M

Howard Hughes Medical Institute and Department of Neuroscience, Brown University, Providence, RI 02912, USA.

Kayser M S

Bear M F

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.288.5469.1254

Published

2000-05-19

Pages

1254-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.288.5469.1254 View journal details

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Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.

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