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PMID: 7969468 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.

Nature ·Vol. 372 ·No. 6503 ·1994-11-17 ·Pages 237-43

Conquet F, Bashir ZI, Davies CH, Daniel H, Ferraguti F, Bordi F, Franz-Bacon K, Reggiani A, Matarese V, Condé F

Abstract

Metabotropic glutamate receptor 1 (mGluR1) is a member of a large family of G-protein-coupled glutamate receptors, the physiological functions of which are largely unknown. Mice deficient in mGluR1 have severe motor coordination and spatial learning deficits. They have no gross anatomical or basic electrophysiological abnormalities in either the cerebellum or hippocampus, but they show impaired cerebellar long-term depression and hippocampal mossy fibre long-term potentiation. mGluR1-deficient mice should therefore be valuable models for studying synaptic plasticity.

Related Genes

mGluR1

MeSH Terms

Animals Base Sequence Cell Line Cerebellum/pathology,physiopathology Electrophysiology Female Hippocampus/pathology,physiopathology Learning Disabilities/genetics Long-Term Potentiation Mice Mice, Inbred C57BL Molecular Sequence Data Motor Activity Mutagenesis Neuromuscular Diseases/genetics,pathology,physiopathology Neuronal Plasticity/physiology Oligodeoxyribonucleotides Purkinje Cells/physiology Receptors, Metabotropic Glutamate/agonists,deficiency,genetics,physiology Synapses/physiology

Chemicals

Oligodeoxyribonucleotides Receptors, Metabotropic Glutamate

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Conquet F

Glaxo Institute for Molecular Biology, Plan-Les-Ouates/Geneva, Switzerland.

Bashir Z I

Davies C H

Daniel H

Ferraguti F

Bordi F

Franz-Bacon K

Reggiani A

Matarese V

Condé F

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/372237a0

Published

1994-11-17

Pages

237-43

Language

English

Region

England

NLM ID

0410462

Subset

Corrections

CommentIn

PMID: 7969463

External Links

PubMed source DOI: 10.1038/372237a0 View journal details

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Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.

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