Home LiteratureArticle Details
PMID: 7968922 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli.

Microbiological reviews ·Vol. 58 ·No. 3 ·1994-09-00 ·Pages 466-90

Calvo JM, Matthews RG

Abstract

The leucine-responsive regulatory protein (Lrp) regulates the expression of more than 40 genes and proteins in Escherichia coli. Among the operons that are positively regulated by Lrp are operons involved in amino acid biosynthesis (ilvIH, serA)), in the biosynthesis of pili (pap, fan, fim), and in the assimilation of ammonia (glnA, gltBD). Negatively regulated operons include operons involved in amino acid catabolism (sdaA, tdh) and peptide transport (opp) and the operon coding for Lrp itself (lrp). Detailed studies of a few members of the regulon have shown that Lrp can act directly to activate or repress transcription of target operons. A substantial fraction of operons regulated by Lrp are also regulated by leucine, and the effect of leucine on expression of these operons requires a functional Lrp protein. The patterns of regulation are surprising and interesting: in some cases activation or repression mediated by Lrp is antagonized by leucine, in other cases Lrp-mediated activation or repression is potentiated by leucine, and in still other cases leucine has no effect on Lrp-mediated regulation. Current research is just beginning to elucidate the detailed mechanisms by which Lrp can mediate such a broad spectrum of regulatory effects. Our view of the role of Lrp in metabolism may change as more members of the regulon are identified and their regulation characterized, but at this point Lrp seems to be important in regulating nitrogen metabolism and one-carbon metabolism, permitting adaptations to feast and to famine.

Related Genes
lrp
MeSH Terms
Amino Acid Sequence Bacterial Proteins/physiology Base Sequence DNA-Binding Proteins/physiology Escherichia coli/genetics Escherichia coli Proteins Gene Expression Regulation, Bacterial/genetics Leucine-Responsive Regulatory Protein Molecular Sequence Data Operon Transcription Factors/physiology
Chemicals
Bacterial Proteins DNA-Binding Proteins Escherichia coli Proteins Lrp protein, E coli Transcription Factors Leucine-Responsive Regulatory Protein
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Calvo J M
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853.
Matthews R G
References (156)
156 references, click to expand
  1. Regulation of the ammonia assimilatory enzymes in Salmonella typhimurium.
    J Bacteriol. 1975 Oct;124(1):182-9 PMID: 240804
  2. Mapping of two loci affecting the regulation of branched-chain amino acid transport in Escherichia coli K-12.
    J Bacteriol. 1976 Apr;126(1):80-90 PMID: 770444
  3. Glutamate dehydrogenase: genetic mapping and isolation of regulatory mutants of Klebsiella aerogenes.
    J Bacteriol. 1976 Jul;127(1):141-8 PMID: 6429
  4. Role of L-threonine dehydrogenase in the catabolism of threonine and synthesis of glycine by Escherichia coli.
    J Bacteriol. 1976 Jun;126(3):1245-9 PMID: 7548
  5. Role of transport systems in amino acid metabolism: leucine toxicity and the branched-chain amino acid transport systems.
    J Bacteriol. 1977 Mar;129(3):1257-65 PMID: 321421
  6. Physiological regulation of a decontrolled lac operon.
    J Bacteriol. 1977 Apr;130(1):212-22 PMID: 323228
  7. Escherichia coli transport mutants lacking binding protein and other components of the branched-chain amino acid transport systems.
    J Bacteriol. 1977 Apr;130(1):384-92 PMID: 323236
  8. The acetohydroxy acid synthase III isoenzyme of Escherichia coli K-12: regulation of synthesis by leucine.
    Biochem Biophys Res Commun. 1977 Nov 7;79(1):82-7 PMID: 336048
  9. gltB gene and regulation of nitrogen metabolism by glutamine synthetase in Escherichia coli.
    J Bacteriol. 1978 Jan;133(1):139-48 PMID: 22535
  10. Regulation of gamma-aminobutyric acid degradation in Escherichia coli by nitrogen metabolism enzymes.
    J Bacteriol. 1978 Feb;133(2):447-51 PMID: 24037
  11. Repression of Escherichia coli pyridine nucleotide transhydrogenase by leucine.
    J Bacteriol. 1978 May;134(2):394-400 PMID: 350821
  12. leu operon of Salmonella typhimurium is controlled by an attenuation mechanism.
    Proc Natl Acad Sci U S A. 1979 Oct;76(10):4941-5 PMID: 388423
  13. A new glnA-linked regulatory gene for glutamine synthetase in Escherichia coli.
    Proc Natl Acad Sci U S A. 1979 Sep;76(9):4544-8 PMID: 41243
  14. Regulation of synthesis of a major outer membrane protein: cyclic AMP represses Escherichia coli protein III synthesis.
    Proc Natl Acad Sci U S A. 1979 Nov;76(11):5520-3 PMID: 230479
  15. Regulation of phosphoglycerate dehydrogenase levels and effect on serine synthesis in Escherichia coli K-12.
    J Bacteriol. 1980 Jan;141(1):235-45 PMID: 6986358
  16. Regulation of cyclic AMP of the ilvB-encoded biosynthetic acetohydroxy acid synthase in Escherichia coli K-12.
    Mol Gen Genet. 1980 Apr;178(1):179-83 PMID: 6247617
  17. Analysis of the nucleotide sequence of an invertible controlling element.
    Proc Natl Acad Sci U S A. 1980 Jul;77(7):4196-200 PMID: 6933466
  18. Biosynthesis of the K99 surface antigen is repressed by alanine.
    Infect Immun. 1980 Oct;30(1):125-8 PMID: 7002786
  19. Locations of the opp and supX genes of Salmonella typhimurium and Escherichia coli.
    J Bacteriol. 1980 Aug;143(2):747-52 PMID: 7009564
  20. Multiple forms of lysyl-transfer ribonucleic acid synthetase in Escherichia coli.
    J Bacteriol. 1981 Apr;146(1):345-51 PMID: 7012120
  21. Acetohydroxy acid synthase isoenzymes of Escherichia coli K-12: a trans-acting regulatory locus of ilvHI gene expression.
    Mol Gen Genet. 1981;181(4):491-6 PMID: 7022128
  22. Physical characterization of the ilvHI operon of Escherichia coli K-12.
    J Bacteriol. 1981 Sep;147(3):797-804 PMID: 6168634
  23. Phase variation of type 1 fimbriae in Escherichia coli is under transcriptional control.
    Science. 1981 Oct 16;214(4518):337-9 PMID: 6116279
  24. Control of leu operon expression in Escherichia coli by a transcription attenuation mechanism.
    J Mol Biol. 1981 Jul 15;149(4):579-97 PMID: 6171647
  25. Acetohydroxy acid synthase is a target for leucine containing peptide toxicity in Escherichia coli.
    J Bacteriol. 1982 Jan;149(1):387-90 PMID: 7033214
  26. Complex glnA-glnL-glnG operon of Escherichia coli.
    J Bacteriol. 1982 Apr;150(1):202-13 PMID: 6120929
  27. Acetohydroxy acid synthase isoenzymes of Escherichia coli K12 and Salmonella typhimurium.
    Ann Microbiol (Paris). 1982 Mar-Apr;133(2):251-6 PMID: 6805381
  28. Host-specific fimbrial adhesins of noninvasive enterotoxigenic Escherichia coli strains.
    Microbiol Rev. 1982 Jun;46(2):129-61 PMID: 6126799
  29. L-Serine deaminase activity is induced by exposure of Escherichia coli K-12 to DNA-damaging agents.
    J Bacteriol. 1982 Nov;152(2):702-5 PMID: 6813312
  30. Isolation of deoxyribonucleic acid methylase mutants of Escherichia coli K-12.
    J Bacteriol. 1973 Jun;114(3):1143-50 PMID: 4576399
  31. Properties of metK mutants of Escherichia coli K-12.
    J Bacteriol. 1973 Jul;115(1):57-67 PMID: 4577753
  32. Multiplicity of leucine transport systems in Escherichia coli K-12.
    J Bacteriol. 1973 Dec;116(3):1258-66 PMID: 4584809
  33. Triornithine-resistant strains of Escherichia coli. Isolation, definition, and genetic studies.
    J Biol Chem. 1974 Jan 10;249(1):143-8 PMID: 4588690
  34. Culture medium for enterobacteria.
    J Bacteriol. 1974 Sep;119(3):736-47 PMID: 4604283
  35. Metabolites influence control of lysine transfer ribonucleic acid synthetase formation in Escherichia coli K-12.
    Proc Natl Acad Sci U S A. 1975 Apr;72(4):1364-7 PMID: 805427
  36. Positive regulation of the Escherichia coli glycine cleavage enzyme system.
    J Bacteriol. 1993 Feb;175(3):902-4 PMID: 8423160
  37. Porin channels in Escherichia coli: studies with liposomes reconstituted from purified proteins.
    J Bacteriol. 1983 Jan;153(1):241-52 PMID: 6294049
  38. Molecular cloning and expression of a gene that controls the high-temperature regulon of Escherichia coli.
    J Bacteriol. 1983 Feb;153(2):597-603 PMID: 6337122
  39. IlvHI locus of Salmonella typhimurium.
    J Bacteriol. 1983 Jun;154(3):1054-63 PMID: 6189818
  40. Molecular structure of ilvIH and its evolutionary relationship to ilvG in Escherichia coli K12.
    Nucleic Acids Res. 1983 Aug 11;11(15):5299-313 PMID: 6308579
  41. Regulation of synthesis of serine hydroxymethyltransferase in chemostat cultures of Escherichia coli.
    J Biol Chem. 1984 Jul 10;259(13):8394-401 PMID: 6376504
  42. K88ab gene of Escherichia coli encodes a fimbria-like protein distinct from the K88ab fimbrial adhesin.
    J Bacteriol. 1984 Aug;159(2):482-7 PMID: 6086572
  43. Genetic characterization and molecular cloning of the tripeptide permease (tpp) genes of Salmonella typhimurium.
    J Bacteriol. 1984 Oct;160(1):122-30 PMID: 6090406
  44. Anaerobic and leucine-dependent expression of a peptide transport gene in Salmonella typhimurium.
    J Bacteriol. 1984 Oct;160(1):131-6 PMID: 6434517
  45. Isolation and characterization of lac fusions to two nitrogen-regulated promoters.
    Mol Gen Genet. 1984;195(1-2):219-27 PMID: 6092849
  46. Isolation and point of action of a factor from Escherichia coli required to reconstruct translation.
    Proc Natl Acad Sci U S A. 1985 Mar;82(6):1648-52 PMID: 3885216
  47. Genetic analysis of the phase variation control of expression of type 1 fimbriae in Escherichia coli.
    J Bacteriol. 1985 May;162(2):668-75 PMID: 2859269
  48. Unusual organization of the ilvIH promoter of Escherichia coli.
    J Bacteriol. 1985 Jul;163(1):186-98 PMID: 3891724
  49. The complete nucleotide sequences of the Escherichia coli LIV-BP and LS-BP genes. Implications for the mechanism of high-affinity branched-chain amino acid transport.
    J Biol Chem. 1985 Jul 15;260(14):8257-61 PMID: 3891753
  50. Metabolic pathway for the utilization of L-arginine, L-ornithine, agmatine, and putrescine as nitrogen sources in Escherichia coli K-12.
    J Bacteriol. 1985 Sep;163(3):933-7 PMID: 3897201
  51. Control of utilization of L-arginine, L-ornithine, agmatine, and putrescine as nitrogen sources in Escherichia coli K-12.
    J Bacteriol. 1985 Sep;163(3):938-42 PMID: 3897202
  52. An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia coli.
    Proc Natl Acad Sci U S A. 1985 Sep;82(17):5724-7 PMID: 2863818
  53. AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli.
    J Bacteriol. 1985 Oct;164(1):310-5 PMID: 2864330
  54. Role of glnB and glnD gene products in regulation of the glnALG operon of Escherichia coli.
    J Bacteriol. 1985 Nov;164(2):816-22 PMID: 2865248
  55. Regulation of peptide transport in Escherichia coli: induction of the trp-linked operon encoding the oligopeptide permease.
    J Bacteriol. 1986 Feb;165(2):428-33 PMID: 3511033
  56. opp-lac Operon fusions and transcriptional regulation of the Escherichia coli trp-linked oligopeptide permease.
    J Bacteriol. 1986 Feb;165(2):434-42 PMID: 3080404
  57. Cooperative binding of lambda repressors to sites separated by integral turns of the DNA helix.
    Cell. 1986 Mar 14;44(5):681-7 PMID: 3948245
  58. DNA bending and its relation to nucleosome positioning.
    J Mol Biol. 1985 Dec 20;186(4):773-90 PMID: 3912515
  59. Two regulatory fim genes, fimB and fimE, control the phase variation of type 1 fimbriae in Escherichia coli.
    EMBO J. 1986 Jun;5(6):1389-93 PMID: 2874022
  60. Genetic characterization of a highly efficient alternate pathway of serine biosynthesis in Escherichia coli.
    J Bacteriol. 1987 Jun;169(6):2611-7 PMID: 3108237
  61. Localization of the receptor-binding protein adhesin at the tip of the bacterial pilus.
    Nature. 1987 Jul 2-8;328(6125):84-7 PMID: 2885755
  62. Fimbrial phase variation in Escherichia coli: dependence on integration host factor and homologies with other site-specific recombinases.
    J Bacteriol. 1987 Aug;169(8):3840-3 PMID: 2886490
  63. Systematic method for the detection of potential lambda Cro-like DNA-binding regions in proteins.
    J Mol Biol. 1987 Apr 5;194(3):557-64 PMID: 3625774
  64. Two novel genes, fanA and fanB, involved in the biogenesis of K99 fimbriae.
    Nucleic Acids Res. 1987 Aug 11;15(15):5973-84 PMID: 2888075
  65. The MerR heavy metal receptor mediates positive activation in a topologically novel transcription complex.
    Cell. 1989 Jan 13;56(1):119-29 PMID: 2910495
  66. The helix-turn-helix DNA binding motif.
    J Biol Chem. 1989 Feb 5;264(4):1903-6 PMID: 2644244
  67. A protein that binds to the regulatory region of the Escherichia coli ilvIH operon.
    J Bacteriol. 1989 Mar;171(3):1658-64 PMID: 2646291
  68. Elevated serine catabolism is associated with the heat shock response in Escherichia coli.
    J Bacteriol. 1989 May;171(5):2619-25 PMID: 2496111
  69. Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements.
    Cell. 1989 May 5;57(3):443-8 PMID: 2566384
  70. Phase-variation of pyelonephritis-associated pili in Escherichia coli: evidence for transcriptional regulation.
    EMBO J. 1989 Feb;8(2):613-20 PMID: 2656260
  71. Molecular characterization of a fimbrial adhesin, F1845, mediating diffuse adherence of diarrhea-associated Escherichia coli to HEp-2 cells.
    J Bacteriol. 1989 Aug;171(8):4281-9 PMID: 2568985
  72. L-serine degradation in Escherichia coli K-12: cloning and sequencing of the sdaA gene.
    J Bacteriol. 1989 Sep;171(9):5095-102 PMID: 2504697
  73. DNA conformation and protein binding.
    Annu Rev Biochem. 1989;58:427-52 PMID: 2673015
  74. Pyrimidine, purine and nitrogen control of cytosine deaminase synthesis in Escherichia coli K 12. Involvement of the glnLG and purR genes in the regulation of codA expression.
    Arch Microbiol. 1989;152(2):115-8 PMID: 2673119
  75. Activation of a cryptic pathway for threonine metabolism via specific IS3-mediated alteration of promoter structure in Escherichia coli.
    J Bacteriol. 1989 Oct;171(10):5503-11 PMID: 2551888
  76. Protein phosphorylation and regulation of adaptive responses in bacteria.
    Microbiol Rev. 1989 Dec;53(4):450-90 PMID: 2556636
  77. Upstream activating sequences that are shared by two divergently transcribed operons mediate cAMP-CRP regulation of pilus-adhesin in Escherichia coli.
    Mol Microbiol. 1989 Nov;3(11):1557-65 PMID: 2575704
  78. Bending of DNA by gene-regulatory proteins: construction and use of a DNA bending vector.
    Gene. 1989 Dec 21;85(1):15-23 PMID: 2533576
  79. Homology of lysS and lysU, the two Escherichia coli genes encoding distinct lysyl-tRNA synthetase species.
    Nucleic Acids Res. 1990 Jan 25;18(2):305-12 PMID: 2183178
  80. Roles of the two lysyl-tRNA synthetases of Escherichia coli: analysis of nucleotide sequences and mutant behavior.
    J Bacteriol. 1990 Jun;172(6):3237-43 PMID: 2188953
  81. Positive control.
    J Biol Chem. 1990 Jul 5;265(19):10797-800 PMID: 2193024
  82. Regulation of the Escherichia coli glyA gene by the purR gene product.
    J Bacteriol. 1990 Jul;172(7):3799-803 PMID: 2113912
  83. Colonization factor antigens of enterotoxigenic Escherichia coli in animals.
    Curr Top Microbiol Immunol. 1990;151:147-65 PMID: 1973369
  84. Novel Escherichia coli K-12 mutants impaired in S-adenosylmethionine synthesis.
    J Bacteriol. 1990 Aug;172(8):4489-96 PMID: 2115868
  85. The leucine regulon of Escherichia coli K-12: a mutation in rblA alters expression of L-leucine-dependent metabolic operons.
    J Bacteriol. 1990 Aug;172(8):4529-35 PMID: 2165479
  86. The ilvIH operon of Escherichia coli is positively regulated.
    J Bacteriol. 1990 Aug;172(8):4563-70 PMID: 2115869
  87. E. coli oriC and the dnaA gene promoter are sequestered from dam methyltransferase following the passage of the chromosomal replication fork.
    Cell. 1990 Sep 7;62(5):967-79 PMID: 1697508
  88. DNA looping and unlooping by AraC protein.
    Science. 1990 Oct 26;250(4980):528-32 PMID: 2237403
  89. Regulation of pap pilin phase variation by a mechanism involving differential dam methylation states.
    EMBO J. 1990 Dec;9(12):4045-54 PMID: 2147413
  90. micF RNA binds to the 5' end of ompF mRNA and to a protein from Escherichia coli.
    Biochemistry. 1990 Oct 2;29(39):9249-56 PMID: 1702997
  91. Physical locations of bglA and serA on the Escherichia coli K-12 chromosome.
    J Bacteriol. 1991 Mar;173(5):1571 PMID: 1999380
  92. Evidence for a methylation-blocking factor (mbf) locus involved in pap pilus expression and phase variation in Escherichia coli.
    J Bacteriol. 1991 Mar;173(5):1789-800 PMID: 1671857
  93. Characterization of Lrp, and Escherichia coli regulatory protein that mediates a global response to leucine.
    J Biol Chem. 1991 Jun 15;266(17):10768-74 PMID: 2040596
  94. Lrp, a global regulatory protein of Escherichia coli, binds co-operatively to multiple sites and activates transcription of ilvIH.
    J Mol Biol. 1993 Jan 20;229(2):306-18 PMID: 8429549
  95. Mutations affecting the ability of Escherichia coli Lrp to bind DNA, activate transcription, or respond to leucine.
    J Bacteriol. 1993 Feb;175(4):1110-7 PMID: 8432705
  96. Regulation of pyelonephritis-associated pili phase-variation in Escherichia coli: binding of the PapI and the Lrp regulatory proteins is controlled by DNA methylation.
    Mol Microbiol. 1993 Feb;7(4):545-53 PMID: 8096319
  97. A stereospecific alignment between the promoter and the cis-acting sequence is required for Lrp-dependent activation of ilvIH transcription in Escherichia coli.
    FEMS Microbiol Lett. 1993 Mar 1;107(2-3):331-6 PMID: 8472914
  98. Derivation of glycine from threonine in Escherichia coli K-12 mutants.
    J Bacteriol. 1975 Jun;122(3):810-7 PMID: 1097400
  99. Transcriptional organization of the F1845 fimbrial adhesin determinant of Escherichia coli.
    Mol Microbiol. 1993 Mar;7(6):993-1006 PMID: 8097864
  100. Lrp, a major regulatory protein in Escherichia coli, bends DNA and can organize the assembly of a higher-order nucleoprotein structure.
    EMBO J. 1993 Jun;12(6):2495-501 PMID: 8508774
  101. The bkdR gene of Pseudomonas putida is required for expression of the bkd operon and encodes a protein related to Lrp of Escherichia coli.
    J Bacteriol. 1993 Jul;175(13):3934-40 PMID: 8320210
  102. Roles of the GcvA and PurR proteins in negative regulation of the Escherichia coli glycine cleavage enzyme system.
    J Bacteriol. 1993 Aug;175(16):5129-34 PMID: 8349552
  103. Subunit association in acetohydroxy acid synthase isozyme III.
    J Bacteriol. 1993 Sep;175(17):5339-43 PMID: 8366022
  104. Cloning and nucleotide sequence of the gcv operon encoding the Escherichia coli glycine-cleavage system.
    Eur J Biochem. 1993 Sep 1;216(2):539-48 PMID: 8375392
  105. Environmental regulation of the fim switch controlling type 1 fimbrial phase variation in Escherichia coli K-12: effects of temperature and media.
    J Bacteriol. 1993 Oct;175(19):6186-93 PMID: 8104927
  106. The leucine-responsive regulatory protein: more than a regulator?
    Trends Biochem Sci. 1993 Jul;18(7):260-3 PMID: 8212136
  107. Regulation of the gltBDF operon of Escherichia coli: how is a leucine-insensitive operon regulated by the leucine-responsive regulatory protein?
    J Bacteriol. 1993 Nov;175(22):7160-9 PMID: 7901196
  108. Isozymes of S-adenosylmethionine synthetase are encoded by tandemly duplicated genes in Escherichia coli.
    Mol Microbiol. 1993 Aug;9(4):835-46 PMID: 8231813
  109. Complex transcriptional control of the sigma s-dependent stationary-phase-induced and osmotically regulated osmY (csi-5) gene suggests novel roles for Lrp, cyclic AMP (cAMP) receptor protein-cAMP complex, and integration host factor in the stationary-phase response of Escherichia coli.
    J Bacteriol. 1993 Dec;175(24):7910-7 PMID: 8253679
  110. Methylation patterns in pap regulatory DNA control pyelonephritis-associated pili phase variation in E. coli.
    Cell. 1994 Feb 11;76(3):577-88 PMID: 7906204
  111. Regulation of the Escherichia coli lrp gene.
    J Bacteriol. 1994 Apr;176(7):1831-9 PMID: 8144448
  112. Leucine-responsive regulatory protein, IS1 insertions, and the negative regulator FaeA control the expression of the fae (K88) operon in Escherichia coli.
    Mol Microbiol. 1994 Feb;11(3):525-36 PMID: 8152376
  113. The H-NS protein modulates the activation of the ilvIH operon of Escherichia coli K12 by Lrp, the leucine regulatory protein.
    Mol Gen Genet. 1994 Mar;242(6):736-43 PMID: 8152423
  114. Analysis of nonmethylated GATC sites in the Escherichia coli chromosome and identification of sites that are differentially methylated in response to environmental stimuli.
    J Bacteriol. 1994 Jun;176(11):3438-41 PMID: 8195106
  115. Leucine-responsive regulatory protein and deoxyadenosine methylase control the phase variation and expression of the sfa and daa pili operons in Escherichia coli.
    Mol Microbiol. 1994 Feb;11(4):605-18 PMID: 7910935
  116. Identification and characterization of stationary phase-inducible genes in Escherichia coli.
    Mol Microbiol. 1993 Oct;10(2):407-20 PMID: 7934831
  117. NUTRITIONAL AND REGULATORY ASPECTS OF SERINE METABOLISM IN ESCHERICHIA COLI.
    J Bacteriol. 1964 Sep;88:611-9 PMID: 14208496
  118. Induced formation of serine and threonine deaminases by Escherichia coli.
    J Bacteriol. 1955 Dec;70(6):667-74 PMID: 13271312
  119. Sequence of thioredoxin reductase from Escherichia coli. Relationship to other flavoprotein disulfide oxidoreductases.
    J Biol Chem. 1988 Jun 25;263(18):9015-9 PMID: 3288628
  120. Organization of Lrp-binding sites upstream of ilvIH in Salmonella typhimurium.
    Mol Microbiol. 1993 Mar;7(6):883-91 PMID: 8483418
  121. Integration host factor is required for the DNA inversion that controls phase variation in Escherichia coli.
    Proc Natl Acad Sci U S A. 1987 Sep;84(18):6506-10 PMID: 2888114
  122. Structural and functional analysis of a cloned segment of Escherichia coli DNA that specifies proteins of a C4 pathway of serine biosynthesis.
    J Bacteriol. 1987 Oct;169(10):4716-21 PMID: 2820941
  123. Molecular characterization of the oligopeptide permease of Salmonella typhimurium.
    J Mol Biol. 1987 May 5;195(1):125-42 PMID: 2821267
  124. Role of type 1 and S fimbriae in the pathogenesis of Escherichia coli O18:K1 bacteremia and meningitis in the infant rat.
    Infect Immun. 1988 Apr;56(4):892-7 PMID: 2894363
  125. Abnormal induction of heat shock proteins in an Escherichia coli mutant deficient in adenosylmethionine synthetase activity.
    J Bacteriol. 1988 Apr;170(4):1582-8 PMID: 3280549
  126. Characterization of a novel L-serine transport system in Escherichia coli.
    J Bacteriol. 1988 May;170(5):2236-9 PMID: 3129404
  127. Functional and structural homology among regulatory cistrons of pili-adhesin determinants in Escherichia coli.
    Mol Gen Genet. 1988 Jun;212(3):412-7 PMID: 2901660
  128. Complete genetic organization and functional aspects of the Escherichia coli S fimbrial adhesion determinant: nucleotide sequence of the genes sfa B, C, D, E, F.
    Microb Pathog. 1990 Nov;9(5):331-43 PMID: 1983079
  129. Transcriptional control--lessons from an E. coli promoter data base.
    Cell. 1991 Aug 9;66(3):415-8 PMID: 1868543
  130. Type 1 fimbriation and fimE mutants of Escherichia coli K-12.
    J Bacteriol. 1991 Sep;173(17):5298-307 PMID: 1679429
  131. Roles of fimB and fimE in site-specific DNA inversion associated with phase variation of type 1 fimbriae in Escherichia coli.
    J Bacteriol. 1991 Sep;173(17):5308-14 PMID: 1679430
  132. The tdh and serA operons of Escherichia coli: mutational analysis of the regulatory elements of leucine-responsive genes.
    J Bacteriol. 1991 Oct;173(19):5944-53 PMID: 1917830
  133. Absence of acetohydroxy acid synthase III in Salmonella typhimurium is due to early termination of translation within the ilvl gene.
    Mol Microbiol. 1991 Jul;5(7):1741-3 PMID: 1943707
  134. Control site location and transcriptional regulation in Escherichia coli.
    Microbiol Rev. 1991 Sep;55(3):371-94 PMID: 1943993
  135. Control of Escherichia coli lysyl-tRNA synthetase expression by anaerobiosis.
    J Bacteriol. 1991 Dec;173(24):7903-10 PMID: 1744045
  136. Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coli.
    J Bacteriol. 1992 Jan;174(1):108-15 PMID: 1729203
  137. Multidegenerate DNA recognition by the OxyR transcriptional regulator.
    J Biol Chem. 1992 Jan 25;267(3):2038-45 PMID: 1730735
  138. Characterization of the regulon controlled by the leucine-responsive regulatory protein in Escherichia coli.
    J Bacteriol. 1992 Feb;174(4):1109-18 PMID: 1346534
  139. The leucine-Lrp regulon in E. coli: a global response in search of a raison d'être.
    Cell. 1992 Feb 21;68(4):617-9 PMID: 1739970
  140. Lambda placMu insertions in genes of the leucine regulon: extension of the regulon to genes not regulated by leucine.
    J Bacteriol. 1992 Mar;174(6):1948-55 PMID: 1532173
  141. Escherichia coli leucine-responsive regulatory protein (Lrp) controls lysyl-tRNA synthetase expression.
    FEBS Lett. 1992 Apr 6;300(3):254-8 PMID: 1555652
  142. The lrp gene product regulates expression of lysU in Escherichia coli K-12.
    J Bacteriol. 1992 May;174(9):2779-84 PMID: 1569010
  143. Escherichia coli cells lacking methylation-blocking factor (leucine-responsive regulatory protein) have precise timing of initiation of DNA replication in the cell cycle.
    J Bacteriol. 1992 May;174(9):3078-82 PMID: 1569034
  144. Isolation of DNA damage-inducible promoters in Escherichia coli: regulation of polB (dinA), dinG, and dinH by LexA repressor.
    J Bacteriol. 1992 May;174(10):3377-85 PMID: 1577702
  145. Leucine-responsive regulatory protein controls the expression of both the pap and fan pili operons in Escherichia coli.
    Proc Natl Acad Sci U S A. 1992 May 15;89(10):4250-4 PMID: 1350087
  146. osmY, a new hyperosmotically inducible gene, encodes a periplasmic protein in Escherichia coli.
    J Bacteriol. 1992 Jun;174(11):3637-44 PMID: 1317380
  147. Physical map locations of the trxB, htrD, cydC, and cydD genes of Escherichia coli.
    J Bacteriol. 1992 Jun;174(11):3824-5 PMID: 1317384
  148. Differential regulation of two genes encoding lysyl-tRNA synthetases in Escherichia coli: lysU-constitutive mutations compensate for a lysS null mutation.
    Mol Microbiol. 1992 Jul;6(13):1739-45 PMID: 1321323
  149. Role of phosphorylated metabolic intermediates in the regulation of glutamine synthetase synthesis in Escherichia coli.
    J Bacteriol. 1992 Oct;174(19):6061-70 PMID: 1356964
  150. Evidence for global regulatory control of pilus expression in Escherichia coli by Lrp and DNA methylation: model building based on analysis of pap.
    Mol Microbiol. 1992 Sep;6(17):2429-35 PMID: 1357527
  151. Properties of recombinant cells capable of growing on serine without NhaB Na+/H+ antiporter in Escherichia coli.
    J Bacteriol. 1992 Nov;174(22):7482-5 PMID: 1331028
  152. In vitro transcription from the Escherichia coli ilvIH promoter.
    J Bacteriol. 1992 Dec;174(23):7648-55 PMID: 1447135
  153. gltF, a member of the gltBDF operon of Escherichia coli, is involved in nitrogen-regulated gene expression.
    Mol Microbiol. 1992 Sep;6(18):2733-41 PMID: 1447980
  154. Lrp stimulates phase variation of type 1 fimbriation in Escherichia coli K-12.
    J Bacteriol. 1993 Jan;175(1):27-36 PMID: 8093239
  155. Multiple control of Escherichia coli lysyl-tRNA synthetase expression involves a transcriptional repressor and a translational enhancer element.
    Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):302-6 PMID: 7678344
  156. Derepressed leucine transport activity in Escherichia coli.
    J Supramol Struct. 1972;1(1):55-9 PMID: 4568192
Article Info
Journal
Microbiological reviews
Abbr.
Microbiol Rev
ISSN
0146-0749
DOI
10.1128/mr.58.3.466-490.1994
Published
1994-09-00
Pages
466-90
Language
English
Region
United States
NLM ID
7806086
PMCID
PMC372976
Subset
IM
Grants
NIGMS NIH HHS · GM39496 · United States
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1128/mr.58.3.466-490.1994 PMC Full Text
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2