Role of L-threonine dehydrogenase in the catabolism of threonine and synthesis of glycine by Escherichia coli.

Journal of bacteriology ·Vol. 126 ·No. 3 ·1976-06-00 ·Pages 1245-9

Newman EB, Kapoor V, Potter R

Abstract

The enzyme L-threonine dehydrogenase was demonstrated in extracts of Escherichia coli K-12, and was shown to be the first enzyme of the pathway converting threonine to glycine. The enzyme was induced by L-leucine, but not by its substrate, L-threonine. The metabolic significance of leucine as a catabolic signal for amino acid degradation is considered.

MeSH Terms

Alcohol Oxidoreductases/metabolism Cell-Free System Enzyme Induction Escherichia coli/enzymology,metabolism Glycine/biosynthesis,metabolism Hydrogen-Ion Concentration Leucine/metabolism Mutation Stereoisomerism Threonine/metabolism

Chemicals

Threonine Alcohol Oxidoreductases Leucine Glycine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Newman E B

Kapoor V

Potter R

References (18)

18 references, click to expand

Regulation of proline catabolism by leucyl,phenylalanyl-tRNA-protein transferase.
Proc Natl Acad Sci U S A. 1975 Jan;72(1):405-8 PMID: 1090937
Derivation of glycine from threonine in Escherichia coli K-12 mutants.
J Bacteriol. 1975 Jun;122(3):810-7 PMID: 1097400
Induced formation of serine and threonine deaminases by Escherichia coli.
J Bacteriol. 1955 Dec;70(6):667-74 PMID: 13271312
The occurrence and determination of delta-amino-levulinic acid and porphobilinogen in urine.
J Biol Chem. 1956 Mar;219(1):435-46 PMID: 13295297
Threonine deamination in Escherichia coli. II. Evidence for two L-threonine deaminases.
J Bacteriol. 1957 Jan;73(1):105-12 PMID: 13405870
Aspects of the metabolism of glycine and of porphyrins.
Biochem J. 1961 Jan;78:1-10 PMID: 13728487
Aminoacetone formation by Staphylococcus aureus.
Biochem J. 1960 Mar;74:478-85 PMID: 13820014
Biosynthesis of alpha-aminoketones and the metabolism of aminoacetone.
J Biol Chem. 1963 Feb;238:811-20 PMID: 13995445
DETERMINATION OF CARBONYL COMPOUNDS WITH N-METHYL BENZOTHIAZOLONE HYDRAZONE.
Arch Biochem Biophys. 1965 Mar;109:548-59 PMID: 14320497
The enzymic formation of aminoacetone from threonine and its further metabolism.
Biochem J. 1964 Sep;92(3):537-49 PMID: 4284408
Studies on L-serine deaminase in Escherichia coli K-12.
J Bacteriol. 1974 Apr;118(1):53-8 PMID: 4595204
Control of serine transhydroxymethylase synthesis in Escherichia coli K12.
Can J Microbiol. 1974 Jan;20(1):41-7 PMID: 4595735
Aminoacyl-tRNA transferases.
Adv Enzymol Relat Areas Mol Biol. 1974;40(0):91-139 PMID: 4599413
Threonine metabolism via two-carbon compounds by Pseudomonas oxalaticus.
J Gen Microbiol. 1971 Aug;67(2):243-6 PMID: 5132279
Microbial metabolism of amino ketones. L-1-aminopropan-2-ol dehydrogenase and L-threonine dehydrogenase in Escherichia coli.
Biochem J. 1967 Jul;104(1):112-21 PMID: 5340733
Utilization of L-threnonine by a pseudomonad: a catabolic role for L-threonine aldolase.
Biochem J. 1969 Nov;115(3):603-5 PMID: 5353532
Properties of threonine deaminase from a bacterium able to use threonine as sole source of carbon.
J Bacteriol. 1969 Nov;100(2):878-89 PMID: 5354953
Utilization of L-threonine by a species of Arthrobacter. A novel catabolic role for "aminoacetone synthase".
Biochem J. 1969 May;112(5):657-71 PMID: 5821726

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.126.3.1245-1249.1976

Published

1976-06-00

Pages

1245-9

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC233149

Subset

External Links

PubMed source DOI: 10.1128/jb.126.3.1245-1249.1976 PMC Full Text View journal details

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Role of L-threonine dehydrogenase in the catabolism of threonine and synthesis of glycine by Escherichia coli.

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