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PMID: 6933466 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Analysis of the nucleotide sequence of an invertible controlling element.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 7 ·1980-07-00 ·Pages 4196-200

Zieg J, Simon M

Abstract

The nucleotide sequence of the inversion region responsible for flagellar phase variation in Salmonella was determined. The inversion region is 995 base pairs (bp) in length and is bounded by a 14-bp inverted repeat sequence. A homologous recombination event between the 14-bp inverted repeat sequences would result in the inversion of the DNA segment between them. Sequence homologies with other systems suggest that the 14-bp inverted repeat sequences may have some general significance as sites for specific recombinational events. The gene which specifies H2 flagellin synthesis begins 16 bp outsie the inversion region. Within the inversion region, an open translational frame exists which could encode a low molecualr weight polypeptide (190 amino acids).

MeSH Terms
Amino Acid Sequence Bacterial Proteins/genetics Base Sequence Chromosome Inversion DNA, Bacterial/genetics Flagellin/genetics Genes, Regulator Operon Plasmids Recombination, Genetic Repetitive Sequences, Nucleic Acid Salmonella/genetics
Chemicals
Bacterial Proteins DNA, Bacterial Flagellin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zieg J
Simon M
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30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.7.4196
Published
1980-07-00
Pages
4196-200
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC349798
Subset
IM
Databases
GENBANK
J01801
External Links
PubMed source DOI: 10.1073/pnas.77.7.4196 PMC Full Text View journal details
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