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PMID: 7565413 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

mRNA stability in mammalian cells.

Microbiological reviews ·Vol. 59 ·No. 3 ·1995-09-00 ·Pages 423-50

Ross J

Abstract

This review concerns how cytoplasmic mRNA half-lives are regulated and how mRNA decay rates influence gene expression. mRNA stability influences gene expression in virtually all organisms, from bacteria to mammals, and the abundance of a particular mRNA can fluctuate manyfold following a change in the mRNA half-life, without any change in transcription. The processes that regulate mRNA half-lives can, in turn, affect how cells grow, differentiate, and respond to their environment. Three major questions are addressed. Which sequences in mRNAs determine their half-lives? Which enzymes degrade mRNAs? Which (trans-acting) factors regulate mRNA stability, and how do they function? The following specific topics are discussed: techniques for measuring eukaryotic mRNA stability and for calculating decay constants, mRNA decay pathways, mRNases, proteins that bind to sequences shared among many mRNAs [like poly(A)- and AU-rich-binding proteins] and proteins that bind to specific mRNAs (like the c-myc coding-region determinant-binding protein), how environmental factors like hormones and growth factors affect mRNA stability, and how translation and mRNA stability are linked. Some perspectives and predictions for future research directions are summarized at the end.

MeSH Terms
Animals Base Sequence Growth Substances/physiology Half-Life Hormones/physiology Ions Mammals Molecular Sequence Data Protein Biosynthesis RNA, Messenger/drug effects,genetics,metabolism Ribonucleases/metabolism Trans-Activators/physiology
Chemicals
Growth Substances Hormones Ions RNA, Messenger Trans-Activators Ribonucleases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ross J
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706, USA.
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Article Info
Journal
Microbiological reviews
Abbr.
Microbiol Rev
ISSN
0146-0749
DOI
10.1128/mr.59.3.423-450.1995
Published
1995-09-00
Pages
423-50
Language
English
Region
United States
NLM ID
7806086
PMCID
PMC239368
Subset
IM
Grants
NCI NIH HHS · CA07175 · United States
NCI NIH HHS · CA23076 · United States
NCI NIH HHS · CA63676 · United States
External Links
PubMed source DOI: 10.1128/mr.59.3.423-450.1995 PMC Full Text
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