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PMID: 2999412 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Rat LINE1: the origin and evolution of a family of long interspersed middle repetitive DNA elements.

Journal of molecular evolution ·Vol. 22 ·No. 2 ·1985-00-00 ·Pages 117-33

Soares MB, Schon E, Efstratiadis A

Abstract

We present approximately 7.0 kb of composite DNA sequence of a long interspersed middle repetitive element (LINE1) present in high copy number in the rat genome. The family of these repeats, which includes transcribing members, is the rat homologue of the mouse MIF-Bam-R and human Kpn I LINEs. Sequence alignments between specimens from these three species define the length of a putative unidentified open reading frame, and document extensive recombination events that, in conjunction with retroposition, have generated this large family of pseudogenes and pseudogene fragments. Comparative mapping of truncated elements indicates that a specific endonucleolytic activity might be involved in illegitimate (nonhomologous) recombination events. Sequence divergence analyses provide insights into the origin and molecular evolution of these elements.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution DNA/genetics DNA Restriction Enzymes Genes Insulin Proinsulin/genetics Protein Precursors/genetics Rats Repetitive Sequences, Nucleic Acid Transcription, Genetic
Chemicals
Insulin Protein Precursors preproinsulin DNA Proinsulin DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Soares M B
Schon E
Efstratiadis A
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70 references, click to expand
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Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF02101690
Published
1985-00-00
Pages
117-33
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
Databases
GENBANK
X03093, X03094, X03095, X03096, X03773
External Links
PubMed source DOI: 10.1007/BF02101690 View journal details
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