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PMID: 2984679 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transposon-like sequences in extrachromosomal circular DNA from mouse thymocytes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 7 ·1985-04-00 ·Pages 2072-6

Fujimoto S, Tsuda T, Toda M, Yamagishi H

Abstract

Small polydisperse circular (spc) DNA was isolated from mouse thymocytes and cloned into the HindIII site of lambda vector Charon 7. Fifty-six recombinants from this spc DNA library were analyzed. R repeats, which were originally found near immunoglobulin genes, were enriched in spc DNA clones relative to their representation in the chromosome. In one clone, the R sequence was linked to Bam and MIF sequences and the contiguous arrangement was truncated from both ends. In another clone, composite Bam/R and R repeats existed as a pair in inverted repeat orientation. Truncation occurred from the 5' side without affecting the 3' ends. In both clones, short direct repeats flanked the repeated sequences. The possible role of R sequences in transposition and circular formation is discussed.

MeSH Terms
Animals Base Sequence Cloning, Molecular DNA Transposable Elements DNA, Circular/analysis Immunoglobulins/genetics Mice Recombination, Genetic Repetitive Sequences, Nucleic Acid T-Lymphocytes/analysis
Chemicals
DNA Transposable Elements DNA, Circular Immunoglobulins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fujimoto S
Tsuda T
Toda M
Yamagishi H
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46 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.7.2072
Published
1985-04-00
Pages
2072-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC397494
Subset
IM
Databases
GENBANK
M11378, M11379, M11380, M11665, M11666
External Links
PubMed source DOI: 10.1073/pnas.82.7.2072 PMC Full Text View journal details
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