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PMID: 6314260 Published · ppublish English Journal Article

Some KpnI family members are associated with the Alu family in the human genome.

Nucleic acids research ·Vol. 11 ·No. 19 ·1983-10-11 ·Pages 6837-46

Miyake T, Migita K, Sakaki Y

Abstract

The structures of the termini and their flanking regions of two human KpnI family members were investigated. The two differed in length, but the starting sequence at one terminal (defined as the 5' terminal) was found to be common to both members. The Alu family sequence was found in the 5' flanking regions. The KpnI family sequence started several base-pairs downstream from the 3' end of the Alu family sequence. In both cases, the Alu family sequence was not flanked by the direct repeat sequence common to the Alu family. These two members showed no sequence homology in 3' terminal regions. Interestingly, the Alu family plus the KpnI family unit was found to be flanked by a direct repeat sequence of several base-pair length. Based on these findings, relationship between the Alu family and KpnI family is discussed.

MeSH Terms
Base Composition Cloning, Molecular DNA/metabolism DNA Restriction Enzymes Genes Globins/genetics Humans Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid Structure-Activity Relationship Transcription, Genetic
Chemicals
Globins DNA DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Miyake T
Migita K
Sakaki Y
References (30)
30 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/11.19.6837
Published
1983-10-11
Pages
6837-46
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326417
Subset
IM
Databases
GENBANK
X01686, X01687, X01688, X01689
External Links
PubMed source DOI: 10.1093/nar/11.19.6837 PMC Full Text View journal details
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