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PMID: 27548222 Published · epublish English Journal Article Review

Multiple Roles of the Small GTPase Rab7.

Cells ·Vol. 5 ·No. 3 ·2016-08-18

Guerra F, Bucci C

Abstract

Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied. Rab7 is fundamental for lysosomal biogenesis, positioning and functions, and for trafficking and degradation of several signaling receptors, thus also having implications on signal transduction. Several Rab7 interacting proteins have being identified leading to the discovery of a number of different important functions, beside its established role in endocytosis. Furthermore, Rab7 has specific functions in neurons. This review highlights and discusses the role and the importance of Rab7 on different cellular pathways and processes.

Keywords
Rab7 apoptosis autophagy endocytosis intermediate filaments lipophagy lysosome membrane traffic mitophagy vesicular transport
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Guerra Flora
Department of Biological and Environmental Sciences and Technologies (DiSTeBA), Università del Salento, Via Provinciale Lecce-Monteroni n. 165, 73100 Lecce, Italy. guerraflora@gmail.com.
Bucci Cecilia
Department of Biological and Environmental Sciences and Technologies (DiSTeBA), Università del Salento, Via Provinciale Lecce-Monteroni n. 165, 73100 Lecce, Italy. cecilia.bucci@unisalento.it.
Conflict of Interest

The authors declare no conflict of interest.

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Article Info
Journal
Cells
Abbr.
Cells
ISSN
2073-4409
DOI
10.3390/cells5030034
Email
guerraflora@gmail.com
cecilia.bucci@unisalento.it
Published
2016-08-18
Epub
2016-00-18
Language
English
Region
Switzerland
NLM ID
101600052
PMCID
PMC5040976
External Links
PubMed source DOI: 10.3390/cells5030034 PMC Full Text View journal details
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