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PMID: 20558439 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Mitochondrial aldehyde dehydrogenase and cardiac diseases.

Cardiovascular research ·Vol. 88 ·No. 1 ·2010-10-01 ·Pages 51-7

Chen CH, Sun L, Mochly-Rosen D

Abstract

Numerous conditions promote oxidative stress, leading to the build-up of reactive aldehydes that cause cell damage and contribute to cardiac diseases. Aldehyde dehydrogenases (ALDHs) are important enzymes that eliminate toxic aldehydes by catalysing their oxidation to non-reactive acids. The review will discuss evidence indicating a role for a specific ALDH enzyme, the mitochondrial ALDH2, in combating oxidative stress by reducing the cellular 'aldehydic load'. Epidemiological studies in humans carrying an inactive ALDH2, genetic models in mice with altered ALDH2 levels, and small molecule activators of ALDH2 all highlight the role of ALDH2 in cardioprotection and suggest a promising new direction in cardiovascular research and the development of new treatments for cardiovascular diseases.

MeSH Terms
Aldehyde Dehydrogenase/genetics,metabolism Aldehyde Dehydrogenase, Mitochondrial Aldehydes/metabolism Animals Enzyme Activation Heart Diseases/enzymology,genetics,therapy Humans Isoenzymes Mitochondria, Heart/enzymology Myocardium/enzymology Oxidation-Reduction Oxidative Stress
Chemicals
Aldehydes Isoenzymes ALDH2 protein, human ALDH2 protein, mouse Aldehyde Dehydrogenase Aldehyde Dehydrogenase, Mitochondrial
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chen Che-Hong
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.
Sun Lihan
Mochly-Rosen Daria
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Article Info
Journal
Cardiovascular research
Abbr.
Cardiovasc Res
ISSN
1755-3245
DOI
10.1093/cvr/cvq192
Published
2010-10-01
Epub
2010-00-16
Pages
51-7
Language
English
Region
England
NLM ID
0077427
PMCID
PMC2936126
Subset
IM
Grants
NIAAA NIH HHS · R37 AA011147 · United States
NIAAA NIH HHS · AA11147 · United States
NIAAA NIH HHS · AA011147 · United States
External Links
PubMed source DOI: 10.1093/cvr/cvq192 PMC Full Text View journal details
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