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PMID: 23702245 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Cellular metabolic and autophagic pathways: traffic control by redox signaling.

Free radical biology & medicine ·Vol. 63 ·2013-10-00 ·Pages 207-21

Dodson M, Darley-Usmar V, Zhang J

Abstract

It has been established that the key metabolic pathways of glycolysis and oxidative phosphorylation are intimately related to redox biology through control of cell signaling. Under physiological conditions glucose metabolism is linked to control of the NADH/NAD redox couple, as well as providing the major reductant, NADPH, for thiol-dependent antioxidant defenses. Retrograde signaling from the mitochondrion to the nucleus or cytosol controls cell growth and differentiation. Under pathological conditions mitochondria are targets for reactive oxygen and nitrogen species and are critical in controlling apoptotic cell death. At the interface of these metabolic pathways, the autophagy-lysosomal pathway functions to maintain mitochondrial quality and generally serves an important cytoprotective function. In this review we will discuss the autophagic response to reactive oxygen and nitrogen species that are generated from perturbations of cellular glucose metabolism and bioenergetic function.

Keywords
4-hydroxy-2-nonenal AMP kinase AMPK Aging Ambra Atg Autophagy B-cell lymphoma 2 BH3 BNIP Bcl-2 Bcl-2 homology domain 3 Bcl-2/adenovirus E18 19-kDa-interacting protein CMA Cardiovascular disease Cellular bioenergetics Diabetes ER ERK ESCRT3 Free radicals G6PD GAPDH GSH GSSG Glucose Glutathione Glycolysis HIF HNE Hsc70 IRE JNK LC3 MEF Mitochondria Mitophagy NADPH oxidase NIP3-like X NIX NOX Neurodegeneration Oxidative stress PI3K PI3P PINK1 PPP PTEN-induced kinase 1 RNS ROS Rab5 Rac1 Ras-associated protein Ras-related C3 botulinum toxin substrate 1 Redox signaling SNARE TIGAR TP53-induced glycolysis and apoptosis regulator TSC ULK1 and ULK2 UV radiation resistance-associated gene protein UVRAG VDAC Vacuolar protein sorting. Vps activating molecule in beclin 1-regulated autophagy autophagy-related gene c-Jun N-terminal kinase chaperone-mediated autophagy eNOS endoplasmic reticulum endosomal sorting complexes required for transport 3 endothelial nitric oxide synthase extracellular signal-regulated kinase glucose-6-phosphate dehydrogenase glutathione glyceraldehyde-3-phosphate dehydrogenase heat shock cognate 70 hypoxia-inducible factor inositol requiring enzyme mTOR mammalian target of rapamycin microtubule-associated protein 1 light-chain subunit 3 mouse embryonic fibroblast oxidized glutathione pentose phosphate pathway phosphatidylinositol 3-phosphate phosphoinositide 3-kinase reactive nitrogen species reactive oxygen species soluble N-ethylmaleimide-sensitive factor attachment protein receptor tuberous sclerosis complex uncoordinated family member-51-like kinases 1 and 2 voltage-dependent anion channel
MeSH Terms
Antioxidants/metabolism Apoptosis Autophagy Glucose/metabolism Humans Lysosomes/metabolism Metabolic Networks and Pathways Mitochondria/metabolism NAD/metabolism Oxidation-Reduction Oxidative Stress Reactive Oxygen Species/metabolism
Chemicals
Antioxidants Reactive Oxygen Species NAD Glucose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dodson Matthew
Center for Free Radical Biology and University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Darley-Usmar Victor
Zhang Jianhua
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Article Info
Journal
Free radical biology & medicine
Abbr.
Free Radic Biol Med
ISSN
1873-4596
DOI
10.1016/j.freeradbiomed.2013.05.014
Published
2013-10-00
Epub
2013-00-20
Pages
207-21
Language
English
Region
United States
NLM ID
8709159
PMCID
PMC3729625
Subset
IM
Grants
NIDDK NIH HHS · R56 DK075865 · United States
NINDS NIH HHS · R01 NS064090 · United States
NIEHS NIH HHS · ES10167 · United States
NIDDK NIH HHS · DK75865 · United States
NIEHS NIH HHS · R01 ES010167 · United States
NIAAA NIH HHS · AA13395 · United States
NIAAA NIH HHS · R01 AA013395 · United States
NINDS NIH HHS · R01-NS064090 · United States
External Links
PubMed source DOI: 10.1016/j.freeradbiomed.2013.05.014 PMC Full Text View journal details
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