p53: The Janus of autophagy?

Nature cell biology ·Vol. 10 ·No. 6 ·2008-06-00 ·Pages 637-9

Levine B, Abrams J

Abstract

The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.

MeSH Terms

Animals Autophagy Cell Transformation, Neoplastic Gene Expression Regulation Genes, p53 Genome Humans Models, Biological Models, Genetic Oxidative Stress Phagosomes Tumor Suppressor Protein p53/metabolism,physiology

Chemicals

Tumor Suppressor Protein p53

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Levine Beth

Abrams John

References (14)

14 references, click to expand

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Article Info

Journal

Nature cell biology

Abbr.

Nat Cell Biol

ISSN

1476-4679

DOI

10.1038/ncb0608-637

Published

2008-06-00

Pages

637-9

Language

English

Region

England

NLM ID

100890575

PMCID

PMC2739720

Subset

Grants

NCI NIH HHS · R01 CA109618 · United States

NCI NIH HHS · R01 CA109618-05 · United States

External Links

PubMed source DOI: 10.1038/ncb0608-637 PMC Full Text View journal details

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p53: The Janus of autophagy?

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