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PMID: 26858267 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Metabolic regulation of mitochondrial dynamics.

The Journal of cell biology ·Vol. 212 ·No. 4 ·2016-02-15 ·Pages 379-87

Mishra P, Chan DC

Abstract

Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they act as powerhouses to generate adenosine triphosphate from oxidation of nutrients. At the same time, these organelles are highly dynamic and undergo fusion, fission, transport, and degradation. Each of these dynamic processes is critical for maintaining a healthy mitochondrial population. Given the central metabolic function of mitochondria, it is not surprising that mitochondrial dynamics and bioenergetics reciprocally influence each other. We review the dynamic properties of mitochondria, with an emphasis on how these processes respond to cellular signaling events and how they affect metabolism.

MeSH Terms
Animals Biological Transport Energy Metabolism Humans Mitochondria/metabolism,pathology Mitochondrial Dynamics Mitophagy Signal Transduction
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mishra Prashant
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Chan David C
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125 dchan@caltech.edu.
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
1540-8140
DOI
10.1083/jcb.201511036
Email
dchan@caltech.edu
Published
2016-02-15
Epub
2016-00-08
Pages
379-87
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC4754720
Subset
IM
Grants
NIGMS NIH HHS · R01 GM110039 · United States
NIGMS NIH HHS · R01 GM119388 · United States
NIGMS NIH HHS · GM110039 · United States
External Links
PubMed source DOI: 10.1083/jcb.201511036 PMC Full Text View journal details
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