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PMID: 25184560 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Picornavirus morphogenesis.

Microbiology and molecular biology reviews : MMBR ·Vol. 78 ·No. 3 ·2014-09-00 ·Pages 418-37

Jiang P, Liu Y, Ma HC, Paul AV, Wimmer E

Abstract

The Picornaviridae represent a large family of small plus-strand RNA viruses that cause a bewildering array of important human and animal diseases. Morphogenesis is the least-understood step in the life cycle of these viruses, and this process is difficult to study because encapsidation is tightly coupled to genome translation and RNA replication. Although the basic steps of assembly have been known for some time, very few details are available about the mechanism and factors that regulate this process. Most of the information available has been derived from studies of enteroviruses, in particular poliovirus, where recent evidence has shown that, surprisingly, the specificity of encapsidation is governed by a viral protein-protein interaction that does not involve an RNA packaging signal. In this review, we make an attempt to summarize what is currently known about the following topics: (i) encapsidation intermediates, (ii) the specificity of encapsidation (iii), viral and cellular factors that are required for encapsidation, (iv) inhibitors of encapsidation, and (v) a model of enterovirus encapsidation. Finally, we compare some features of picornavirus morphogenesis with those of other plus-strand RNA viruses.

MeSH Terms
Animals Antiviral Agents/pharmacology Capsid/physiology,ultrastructure Genome, Viral Host-Pathogen Interactions Humans Morphogenesis Picornaviridae/drug effects,physiology,ultrastructure Picornaviridae Infections/virology RNA, Viral/physiology Virus Assembly
Chemicals
Antiviral Agents RNA, Viral
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Jiang Ping
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
Liu Ying
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
Ma Hsin-Chieh
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
Paul Aniko V
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
Wimmer Eckard
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA eckard.wimmer@stonybrook.edu.
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1098-5557
DOI
10.1128/MMBR.00012-14
Email
eckard.wimmer@stonybrook.edu
Published
2014-09-00
Pages
418-37
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC4187686
Subset
IM
Grants
NIAID NIH HHS · R01 AI015122 · United States
NIAID NIH HHS · R37 AI015122 · United States
NIAID NIH HHS · AI 15122 · United States
External Links
PubMed source DOI: 10.1128/MMBR.00012-14 PMC Full Text View journal details
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