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PMID: 212582 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Poliovirus single-stranded RNA and double-stranded RNA: differential infectivity in enucleate cells.

Journal of virology ·Vol. 27 ·No. 3 ·1978-09-00 ·Pages 582-6

Detjen BM, Lucas J, Wimmer E

Abstract

The ability of poliovirus virion RNA and double-stranded RNA (replicative form) to replicate in enucleate mouse L cells was investigated. Virion RNA replicated successfully in the absence of the cell nucleus, whereas replicative form infection did not produce any detectable progeny in enucleate cells. The results provide direct evidence of a nuclear requirement early in the infection initiated by replicative form RNA.

MeSH Terms
Cell Nucleus/drug effects,metabolism Cytochalasin B/pharmacology Cytoplasm/metabolism HeLa Cells L Cells Poliovirus/drug effects,growth & development,metabolism RNA, Viral/biosynthesis Virus Replication/drug effects
Chemicals
RNA, Viral Cytochalasin B
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Detjen B M
Lucas J
Wimmer E
References (43)
43 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.27.3.582-586.1978
Published
1978-09-00
Pages
582-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC525845
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.27.3.582-586.1978 PMC Full Text View journal details
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