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PMID: 2303040 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

An interspersed repeated sequence specific for human subtelomeric regions.

The EMBO journal ·Vol. 9 ·No. 2 ·1990-02-00 ·Pages 505-14

Rouyer F, de la Chapelle A, Andersson M, Weissenbach J

Abstract

A family of DNA loci (DNF28) from the pseudoautosomal region of the human sex chromosomes is characterized by a repeated element (STIR: subtelomeric interspersed repeat) which detects homologous sequences in the telomeric regions of human autosomes by in situ hybridization. Several STIR elements from both the pseudoautosomal region and terminal parts of autosomes were cloned and sequenced. A conserved 350 bp sequence and some characteristic structural differences between the autosomal and pseudoautosomal STIRs were observed. Screening of the DNA sequence databases with a consensus sequence revealed the presence of STIRs in several human loci localized in the terminal parts of different chromosomes. We mapped single copy probes flanking the cloned autosomal STIRs to the subtelomeric parts of six different chromosomes by in situ hybridization and genetic linkage analysis. The linkage data show a greatly increased recombination frequency in the subtelomeric regions of the chromosomes, especially in male meiosis. The STIR elements, specifically located in subtelomeric regions, could play a role in the peculiar recombination properties of these chromosomal regions, e.g. by promoting initiation of pairing at meiosis.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Blotting, Southern Chromosome Mapping Cloning, Molecular Cricetinae DNA/genetics,isolation & purification DNA Probes Female Gene Library Humans Hybrid Cells/cytology Information Systems Male Meiosis Metaphase Molecular Sequence Data Nucleic Acid Hybridization Reference Values Repetitive Sequences, Nucleic Acid Sequence Homology, Nucleic Acid X Chromosome
Chemicals
DNA Probes DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rouyer F
Unité de Recombinaison et Expression Génétique, INSERM U163, CNRS UA271, Institut Pasteur, Paris, France.
de la Chapelle A
Andersson M
Weissenbach J
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1990-02-00
Pages
505-14
Language
English
Region
England
NLM ID
8208664
PMCID
PMC551693
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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