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PMID: 3859205 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.

American journal of human genetics ·Vol. 37 ·No. 3 ·1985-05-00 ·Pages 482-98

Lathrop GM, Lalouel JM, Julier C, Ott J

Abstract

Multilocus linkage analysis is investigated from the viewpoint of the efficiency of recombination estimates under different strategies for detecting linkage and determining gene order within a linkage group. We consider the appropriateness of assuming no interference with data available in human genetic studies. Examples are given to show the significance of multilocus analysis in humans. A computer program package, LINKAGE, for multilocus linkage analysis is described.

MeSH Terms
Chromosome Mapping Genes Genetic Linkage Genetic Markers Humans Models, Genetic Pedigree Probability Recombination, Genetic
Chemicals
Genetic Markers
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lathrop G M
Lalouel J M
Julier C
Ott J
References (16)
16 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1985-05-00
Pages
482-98
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1684598
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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