A pseudoautosomal gene in man.

Science (New York, N.Y.) ·Vol. 234 ·No. 4777 ·1986-11-07 ·Pages 740-3

Goodfellow PJ, Darling SM, Thomas NS, Goodfellow PN

Abstract

The X/Y homologous gene MIC2 was shown to exchange between the sex chromosomes, thus demonstrating that it is a pseudoautosomal gene in man. MIC2 recombines with the sex-determining gene(s) TDF at a frequency of 2 to 3 percent. It is the most proximal pseudoautosomal locus thus far described and as such is an important marker for use in studies directed towards the isolation of TDF.

MeSH Terms

Chromosome Mapping Genes Genetic Linkage Humans Pedigree Polymorphism, Restriction Fragment Length Recombination, Genetic Sex Chromosome Aberrations/genetics Sex Determination Analysis X Chromosome Y Chromosome

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Goodfellow P J

Darling S M

Thomas N S

Goodfellow P N

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.2877492

Published

1986-11-07

Pages

740-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.2877492 View journal details

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