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PMID: 22473383 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Histone methylation: a dynamic mark in health, disease and inheritance.

Nature reviews. Genetics ·Vol. 13 ·No. 5 ·2012-04-03 ·Pages 343-57

Greer EL, Shi Y

Abstract

Organisms require an appropriate balance of stability and reversibility in gene expression programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation is integral to this dynamic control. Post-translational modification of histones by methylation is an important and widespread type of chromatin modification that is known to influence biological processes in the context of development and cellular responses. To evaluate how histone methylation contributes to stable or reversible control, we provide a broad overview of how histone methylation is regulated and leads to biological outcomes. The importance of appropriately maintaining or reprogramming histone methylation is illustrated by its links to disease and ageing and possibly to transmission of traits across generations.

MeSH Terms
Animals Caenorhabditis/metabolism Drosophila/metabolism Epigenesis, Genetic Female Histone Demethylases/metabolism Histone Methyltransferases Histone-Lysine N-Methyltransferase/metabolism Histones/metabolism Humans Male Methylation Mice Neoplasms/metabolism Protein Processing, Post-Translational Rats
Chemicals
Histones Histone Demethylases Histone Methyltransferases Histone-Lysine N-Methyltransferase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Greer Eric L
Cell Biology Department, Harvard Medical School and Division of Newborn Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
Shi Yang
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg3173
Published
2012-04-03
Epub
2012-00-03
Pages
343-57
Language
English
Region
England
NLM ID
100962779
PMCID
PMC4073795
Subset
IM
Grants
NIGMS NIH HHS · R01 GM071004 · United States
PHS HHS · NCI118487 · United States
NCI NIH HHS · R01 CA118487 · United States
NIGMS NIH HHS · R01 GM058012 · United States
NIGMS NIH HHS · GM058012 · United States
NIGMS NIH HHS · GM071004 · United States
External Links
PubMed source DOI: 10.1038/nrg3173 PMC Full Text View journal details
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