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PMID: 19703438 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Histone H3 lysine 4 (H3K4) methylation in development and differentiation.

Developmental biology ·Vol. 339 ·No. 2 ·2010-03-15 ·Pages 240-9

Eissenberg JC, Shilatifard A

Abstract

Covalent modification of histones on chromatin is a dynamic mechanism by which various nuclear processes are regulated. Methylation of histone H3 on lysine 4 (H3K4) implemented by the macromolecular complex COMPASS and its related complexes is associated with transcriptionally active regions of chromatin. Enzymes that catalyze H3K4 methylation were initially characterized genetically as regulators of Hox loci, long before their catalytic functions were recognized. Since their discovery, genetic and biochemical studies of H3K4 methylases and demethylases have provided important mechanistic insight into the role of H3K4 methylation in HOX gene regulation during development.

MeSH Terms
Animals Cell Differentiation Chromatin/metabolism Drosophila/genetics,metabolism Gene Expression Regulation, Developmental Genes, Homeobox Histones/chemistry,metabolism Humans Lysine/genetics,metabolism Methylation Models, Biological Nuclear Proteins/genetics,metabolism
Chemicals
Chromatin Histones Nuclear Proteins Lysine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Eissenberg Joel C
Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA. eissenjc@slu.edu
Shilatifard Ali
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Article Info
Journal
Developmental biology
Abbr.
Dev Biol
ISSN
1095-564X
DOI
10.1016/j.ydbio.2009.08.017
Email
eissenjc@slu.edu
Published
2010-03-15
Epub
2009-00-21
Pages
240-9
Language
English
Region
United States
NLM ID
0372762
PMCID
PMC3711867
Subset
IM
Grants
NCI NIH HHS · R01 CA089455 · United States
NCI NIH HHS · R01CA89455 · United States
NIGMS NIH HHS · R01GM069905 · United States
NCI NIH HHS · R01 CA150265 · United States
NIGMS NIH HHS · R01 GM069905 · United States
External Links
PubMed source DOI: 10.1016/j.ydbio.2009.08.017 PMC Full Text View journal details
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