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PMID: 2185740 Published · ppublish English Journal Article Review

Nitrogen metabolism in liver: structural and functional organization and physiological relevance.

The Biochemical journal ·Vol. 267 ·No. 2 ·1990-04-15 ·Pages 281-90

Haüssinger D

Abstract

暂无摘要

MeSH Terms
Animals Humans Liver/anatomy & histology,metabolism,physiology Nitrogen/metabolism
Chemicals
Nitrogen
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Haüssinger D
Medizinische Universitätsklinik, Freiburg, Federal Republic of Germany.
References (120)
120 references, click to expand
  1. Activities of Krebs-Henseleit enzymes in normal and cirrhotic human liver.
    J Lab Clin Med. 1974 Nov;84(5):708-15 PMID: 4283792
  2. Urea synthesis and CO2/HCO3- compartmentation in isolated perfused rat liver.
    Biol Chem Hoppe Seyler. 1986 Aug;367(8):741-50 PMID: 3094554
  3. Development of enzymic zonation in liver parenchyma is related to development of acinar architecture.
    Differentiation. 1987;35(3):228-35 PMID: 2895721
  4. Functional specialization of different hepatocyte populations.
    Physiol Rev. 1989 Jul;69(3):708-64 PMID: 2664826
  5. Respiration-dependent transport of carbon dioxide into rat liver mitochondria.
    Biochemistry. 1973 Feb 27;12(5):976-82 PMID: 4631372
  6. Hepatic enzymic zonation: a reevaluation of the concept of the liver acinus.
    Hepatology. 1989 Jul;10(1):72-6 PMID: 2472341
  7. Distribution of hepatic glutaminase activity and mRNA in perivenous and periportal rat hepatocytes.
    Biochem J. 1990 Apr 1;267(1):265-7 PMID: 1970242
  8. Hormonal stimulation of mitochondrial glutaminase. Effects of vasopressin, angiotensin II, adrenaline and glucagon.
    Biochem J. 1983 Mar 15;210(3):957-60 PMID: 6870814
  9. Heterogeneous distribution of glutamine synthetase during rat liver development.
    J Histochem Cytochem. 1987 Jan;35(1):49-54 PMID: 2878950
  10. Hepatic glutamine metabolism under the influence of the portal ammonia concentration in the perfused rat liver.
    Eur J Biochem. 1979 Nov 1;101(1):179-84 PMID: 510303
  11. Localization of ammonia-metabolizing enzymes in human liver: ontogenesis of heterogeneity.
    Hepatology. 1989 Mar;9(3):367-72 PMID: 2563984
  12. The effect of ammonium chloride and glucagon on the metabolism of glutamine in isolated liver cells from starved rats.
    Biochim Biophys Acta. 1978 Sep 21;543(1):16-28 PMID: 708783
  13. Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P450, compared with three further P450-isoenzymes, NADPH P450-reductase, glutathione transferases and microsomal epoxide hydrolase.
    Carcinogenesis. 1984 Aug;5(8):993-1001 PMID: 6430587
  14. Control of ammonia distribution ratio across the liver cell membrane and of ureogenesis by extracellular pH.
    Eur J Biochem. 1986 Jul 15;158(2):283-8 PMID: 3089783
  15. Regulation of hepatic glutamine metabolism.
    Biochem Soc Trans. 1986 Dec;14(6):1001-4 PMID: 2880775
  16. Control of hepatic utilization of glutamine by transport processes or cellular metabolism in rats fed a high protein diet.
    J Nutr. 1988 May;118(5):569-78 PMID: 3367236
  17. Role of glutamine in adaptations in nitrogen metabolism during fasting.
    Am J Physiol. 1986 Jun;250(6 Pt 1):E622-8 PMID: 3521309
  18. Allosteric properties of phosphate-activated glutaminase of human liver mitochondria.
    Biochim Biophys Acta. 1984 Mar 22;798(1):21-7 PMID: 6704422
  19. The apparent Km of ammonia for carbamoyl phosphate synthetase (ammonia) in situ.
    Biochem J. 1985 Jul 1;229(1):205-11 PMID: 4038255
  20. Functional hepatocyte heterogeneity. Vascular 2-oxoglutarate is almost exclusively taken up by perivenous, glutamine-synthetase-containing hepatocytes.
    Eur J Biochem. 1989 May 15;181(3):709-16 PMID: 2567236
  21. Liver carbonic anhydrase and urea synthesis. The effect of diuretics.
    Biochem Pharmacol. 1986 Oct 1;35(19):3317-22 PMID: 3094538
  22. Alterations of hepatic enzyme levels and of the acinar distribution of glutamine synthetase in response to experimental liver injury in the rat.
    Hepatology. 1988 Jul-Aug;8(4):822-30 PMID: 2899050
  23. Hepatocyte heterogeneity in response to extracellular ATP.
    Eur J Biochem. 1987 Dec 15;169(3):645-50 PMID: 3691513
  24. Hormonal regulation of amino acid transport system N in primary cultures of rat hepatocytes.
    Eur J Biochem. 1987 Jul 15;166(2):339-44 PMID: 3301340
  25. pH dependence of hormonal regulation of gluconeogenesis and urea synthesis from glutamine in suspensions of hepatocytes.
    J Biol Chem. 1985 Jan 10;260(1):407-14 PMID: 2981210
  26. Noradrenergic innervation of developing rat and spiny mouse liver. Its relation to the development of the liver architecture and enzymic zonation.
    Anat Embryol (Berl). 1988;178(2):175-81 PMID: 3394957
  27. Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver.
    Eur J Biochem. 1983 Jun 15;133(2):269-75 PMID: 6852039
  28. Regulation of mRNA levels of rat liver carbamoylphosphate synthetase by glucocorticosteroids and cyclic AMP as estimated with a specific cDNA.
    Biochem Biophys Res Commun. 1984 Nov 14;124(3):882-8 PMID: 6210082
  29. Characterization of glutamine transport by liver plasma membrane vesicles.
    Am J Physiol. 1986 Nov;251(5 Pt 1):E509-14 PMID: 3777161
  30. Transient hyperammonemia of the preterm infant.
    N Engl J Med. 1978 Oct 26;299(17):920-5 PMID: 692597
  31. CO2 metabolism in the liver.
    Arch Biochem Biophys. 1983 Apr 15;222(2):442-8 PMID: 6405697
  32. The effect of glutamine administration on urinary ammonium excretion in normal subjects and patients with renal disease.
    J Clin Invest. 1972 Jul;51(7):1852-60 PMID: 4555786
  33. Dual-digitonin-pulse perfusion. Concurrent sampling of periportal and perivenous cytosol of rat liver for determination of metabolites and enzyme activities.
    Biochem J. 1987 Apr 1;243(1):87-95 PMID: 3606584
  34. Development of the heterogeneous distribution of carbamoyl-phosphate synthetase (ammonia) in rat-liver parenchyma during postnatal development.
    J Histochem Cytochem. 1985 Dec;33(12):1205-11 PMID: 4067274
  35. The effect of urea synthesis on extracellular pH in isolated perfused rat liver.
    Biochem J. 1986 May 15;236(1):261-5 PMID: 3790075
  36. Activation of pyruvate dehydrogenase during metabolism of ammonium ions in hemoglobin-free perfused rat liver.
    Eur J Biochem. 1975 Apr 1;52(3):421-31 PMID: 1236139
  37. Hepatic glutaminase flux regulation of glutamine homeostasis. Studies in vivo.
    Biol Chem Hoppe Seyler. 1986 Apr;367(4):301-5 PMID: 3718673
  38. Control of the levels of free amino acids in plasma by the liver.
    Biochem Z. 1965 Dec 31;343(4):407-15 PMID: 5875440
  39. Modulation of the activity of rat liver acetylglutamate synthase by pH and arginine concentration.
    Arch Biochem Biophys. 1985 Nov 15;243(1):100-7 PMID: 4062297
  40. Asymptomatic hyperammonemia in low birthweight infants.
    Pediatr Res. 1978 Mar;12(3):221-4 PMID: 643393
  41. Localization and some properties of phosphate-dependent glutaminase in disrupted liver mitochondria.
    Biochem J. 1980 Nov 15;192(2):537-42 PMID: 7236224
  42. Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs.
    J Biol Chem. 1980 May 10;255(9):4011-9 PMID: 7372663
  43. Acid-base induced alterations in glutamine metabolism and ureogenesis in perfused muscle and liver of the rat.
    Eur J Clin Invest. 1977 Oct;7(5):445-9 PMID: 411675
  44. Acid-base regulation of hepatic glutamine degradation.
    Contrib Nephrol. 1988;63:161-6 PMID: 2847896
  45. Metabolic zonation of liver parenchyma: significance for the regulation of glycogen metabolism, gluconeogenesis, and glycolysis.
    Diabetes Metab Rev. 1987 Jan;3(1):269-93 PMID: 3552523
  46. Hepatocyte heterogeneity in ammonia metabolism: impairment of glutamine synthesis in CCl4 induced liver cell necrosis with no effect on urea synthesis.
    Chem Biol Interact. 1984 Feb;48(2):191-4 PMID: 6697421
  47. Short-term metabolic fate of [13N]ammonia in rat liver in vivo.
    J Biol Chem. 1987 Jan 25;262(3):1073-80 PMID: 2879838
  48. pH control of hepatic glutamine degradation. Role of transport.
    Eur J Biochem. 1987 Jul 15;166(2):483-8 PMID: 3609022
  49. Glutamine metabolism in isolated perfused rat liver. The transamination pathway.
    Biol Chem Hoppe Seyler. 1985 Jun;366(6):527-36 PMID: 2862885
  50. Studies on the metabolism of amino acids and related compounds in vivo. VI. Free amino acid levels in the tissues of rats protected against ammonia toxicity.
    Arch Biochem Biophys. 1957 May;68(1):161-71 PMID: 13435905
  51. Carbamoylphosphate synthetase I of rat-liver mitochondria. Purification, properties, and polypeptide molecular weight.
    Eur J Biochem. 1978 Apr 17;85(2):373-83 PMID: 206435
  52. Reciprocal regulation of glutamine synthetase and carbamoylphosphate synthetase levels in rat liver.
    Biochim Biophys Acta. 1987 Apr 29;908(3):231-40 PMID: 2882780
  53. Cytochemical demonstration of ornithine carbamoyltransferase activity in liver mitochondria of rat and mouse.
    J Histochem Cytochem. 1968 Mar;16(3):172-80 PMID: 4172322
  54. Carbamoyl phosphate synthetase I of human liver. Purification, some properties and immunological cross-reactivity with the rat liver enzyme.
    Biochim Biophys Acta. 1981 May 14;659(1):150-60 PMID: 7248316
  55. The role or urea synthesis in the removal of metabolic bicarbonate and the regulation of blood pH.
    Curr Top Cell Regul. 1982;21:261-302 PMID: 6291855
  56. Functional hepatocyte heterogeneity in ammonia metabolism. The intercellular glutamine cycle.
    J Hepatol. 1985;1(1):3-14 PMID: 2865284
  57. The role of growth hormone, dexamethasone and triiodothyronine in the regulation of glutamine synthetase in primary cultures of rat hepatocytes.
    Eur J Biochem. 1979 Oct 15;100(2):519-25 PMID: 41714
  58. Analysis of the control of citrulline synthesis in isolated rat-liver mitochondria.
    Eur J Biochem. 1984 Jul 16;142(2):247-54 PMID: 6745275
  59. Glutamine synthetase from rat liver. Purification, properties, and preparation of specific antisera.
    J Biol Chem. 1978 Sep 10;253(17):6111-8 PMID: 28323
  60. Hepatocyte heterogeneity in glutamate metabolism and bidirectional transport in perfused rat liver.
    Eur J Biochem. 1989 Oct 20;185(1):189-95 PMID: 2572417
  61. Ammonia and glutamine metabolism in human liver slices: new aspects on the pathogenesis of hyperammonaemia in chronic liver disease.
    Eur J Clin Invest. 1988 Oct;18(5):535-42 PMID: 3147907
  62. Interactions between glutamine metabolism and cell-volume regulation in perfused rat liver.
    Eur J Biochem. 1990 Mar 30;188(3):689-95 PMID: 2331991
  63. Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture.
    EMBO J. 1983;2(4):567-70 PMID: 6138251
  64. Effect of trifluoperazine on the stimulation by Ca2+-dependent hormones of gluconeogenesis from glutamine in isolated hepatocytes.
    Biochim Biophys Acta. 1981 Nov 5;677(3-4):506-11 PMID: 7295808
  65. Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver.
    Biochim Biophys Acta. 1983 Jan 25;755(2):272-8 PMID: 6131695
  66. Glutamine balance in metabolic acidosis as studied with the artificial kidney.
    Am J Physiol. 1968 Aug;215(2):278-81 PMID: 5665156
  67. Distribution of glutamine synthetase and carbamoyl-phosphate synthetase I in vertebrate liver.
    Proc Natl Acad Sci U S A. 1988 Jan;85(1):160-4 PMID: 2893372
  68. The role of pH and the lack of a requirement for hydorgencarbonate in the regulation of hepatic glutamine metabolism.
    Hoppe Seylers Z Physiol Chem. 1980 Jul;361(7):995-101 PMID: 7409750
  69. Possible growth hormone control of liver glutamine synthetase activity in rats.
    Endocrinology. 1980 Jan;106(1):268-74 PMID: 6101267
  70. Methods for the study of liver cell heterogeneity.
    Histochem J. 1989 Sep-Oct;21(9-10):517-29 PMID: 2687211
  71. Control of ureogenesis.
    Eur J Biochem. 1985 Apr 1;148(1):189-96 PMID: 3979393
  72. Characteristics of the activation of glutaminase by ammonia in sonicated rat liver mitochondria.
    Biochim Biophys Acta. 1983 Sep 13;759(3):296-302 PMID: 6136301
  73. Mitochondrial carbonic anhydrase.
    Proc Natl Acad Sci U S A. 1980 Sep;77(9):5562-6 PMID: 6776540
  74. Urea synthesis in freshly isolated and in cultured periportal and perivenous hepatocytes.
    Biochem J. 1986 Oct 15;239(2):263-7 PMID: 3814074
  75. Permissive effect of dexamethasone on glucagon induction of urea-cycle enzymes in perifused primary monolayer cultures of rat hepatocytes.
    Eur J Biochem. 1979 Jun;97(1):29-35 PMID: 477671
  76. Channeling of ammonia from glutaminase to carbamoyl-phosphate synthetase in liver mitochondria.
    FEBS Lett. 1985 Oct 28;191(2):249-51 PMID: 4054309
  77. Bidirectional transport of glutamine across the cell membrane in rat liver.
    Biochem J. 1983 Nov 15;216(2):401-8 PMID: 6661205
  78. Different proliferative activity in vitro of periportal and perivenous hepatocytes.
    Scand J Gastroenterol Suppl. 1988;151:8-18 PMID: 2906480
  79. The microcirculatory acinar concept of normal and pathological hepatic structure.
    Beitr Pathol. 1976 May;157(3):215-43 PMID: 1275864
  80. Human carbamylphosphate synthetase I. Stabilization, purification, and partial characterization of the enzyme from human liver.
    J Biol Chem. 1980 Aug 25;255(16):7891-5 PMID: 6249820
  81. Pathophysiology of metabolic acidosis: effect of low pH on the hepatic uptake of lactate, pyruvate and alanine.
    Clin Physiol. 1982 Feb;2(1):51-8 PMID: 7201908
  82. Contribution of matrix carbonic anhydrase to citrulline synthesis in isolated guinea pig liver mitochondria.
    J Biol Chem. 1983 Jun 25;258(12):7696-701 PMID: 6408083
  83. UREA CYCLE ENZYMATIC ABNORMALITIES IN PATIENTS IN ENDOGENOUS HEPATIC COMA.
    Gastroenterology. 1963 Aug;45:182-8 PMID: 14051729
  84. Vasopressin and angiotensin II stimulate ureogenesis through increased mitochondrial citrulline production.
    Life Sci. 1982 Nov 29;31(22):2493-8 PMID: 7154849
  85. Control by pH of urea synthesis in isolated rat hepatocytes.
    Eur J Biochem. 1988 Mar 1;172(2):465-9 PMID: 3350009
  86. Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency.
    J Clin Invest. 1980 May;65(5):1162-73 PMID: 7364943
  87. Hepatocyte heterogeneity in glutamate uptake by isolated perfused rat liver.
    Eur J Biochem. 1983 Nov 2;136(2):421-5 PMID: 6414814
  88. Different capacities for amino acid transport in periportal and perivenous hepatocytes isolated by digitonin/collagenase perfusion.
    Hepatology. 1989 Jan;9(1):22-8 PMID: 2562797
  89. Regulation of hepatic glutamate metabolism. Role of 2-oxoacids in glutamate release from isolated perfused rat liver.
    Eur J Biochem. 1984 Sep 17;143(3):491-7 PMID: 6479162
  90. Short-term metabolic fate of 13N-labeled glutamate, alanine, and glutamine(amide) in rat liver.
    J Biol Chem. 1988 Sep 5;263(25):12268-73 PMID: 2900834
  91. Ammonium and bicarbonate homeostasis in chronic liver disease.
    Klin Wochenschr. 1990 Feb 1;68(3):175-82 PMID: 2314005
  92. Hepatic urea synthesis and pH regulation. Role of CO2, HCO3-, pH and the activity of carbonic anhydrase.
    Eur J Biochem. 1985 Oct 15;152(2):381-6 PMID: 3932068
  93. Cell heterogeneity within the hepatic lobule: quantitative histochemistry.
    J Histochem Cytochem. 1959 Jul;7(4):237-9 PMID: 13664970
  94. Acid-base disturbances in liver disease.
    J Hepatol. 1986;2(2):299-306 PMID: 3958478
  95. Heterogeneous expression of glutamine synthetase mRNA in rat liver parenchyma revealed by in situ hybridization and Northern blot analysis of RNA from periportal and perivenous hepatocytes.
    FEBS Lett. 1988 Dec 5;241(1-2):89-93 PMID: 2904380
  96. Control of rat-liver glutaminase by ammonia and pH.
    Eur J Biochem. 1983 Jun 1;133(1):241-4 PMID: 6852030
  97. Differential effects of starvation on alanine and glutamine transport in isolated rat hepatocytes.
    Biochem J. 1982 Apr 15;204(1):365-8 PMID: 7115327
  98. Characteristics of the transport of alanine, serine and glutamine across the plasma membrane of isolated rat liver cells.
    Biochem J. 1978 Dec 15;176(3):827-36 PMID: 747655
  99. The diagnostic significance of liver cell inhomogeneity: serum enzymes in patients with central liver necrosis and the distribution of glutamate dehydrogenase in normal human liver.
    Z Klin Chem Klin Biochem. 1975 Jul;13(7):311-8 PMID: 1189532
  100. Immunohistochemical localization of carbamoyl-phosphate synthetase (ammonia) in adult rat liver; evidence for a heterogeneous distribution.
    J Histochem Cytochem. 1984 Jun;32(6):557-64 PMID: 6373912
  101. Urea synthesis from ammonia in periportal and pericentral regions of the liver lobule. Effect of oxygen.
    Eur J Biochem. 1987 Feb 16;163(1):1-7 PMID: 3816789
  102. Urea excretion as a strategy for survival in a fish living in a very alkaline environment.
    Nature. 1989 Jan 12;337(6203):165-6 PMID: 2911349
  103. Water, K+, H+, lactate and glucose fluxes during cell volume regulation in perfused rat liver.
    Pflugers Arch. 1989 Jan;413(3):209-16 PMID: 2717371
  104. Changes in distribution of enzymes within the liver lobule during adaptive increases.
    J Histochem Cytochem. 1972 Feb;20(2):107-11 PMID: 4400699
  105. Perivenous localisation of Na-dependent glutamate transport in perfused rat liver.
    FEBS Lett. 1987 Sep 14;221(2):370-4 PMID: 2887456
  106. Induction of glutamine synthetase and transient co-expression with carbamoylphosphate synthetase in hepatocytes transplanted into fat pads of syngeneic hosts.
    Histochemistry. 1989;92(4):337-42 PMID: 2572574
  107. Metabolic aspects of the regulation of systemic pH.
    Am J Physiol. 1987 Jun;252(6 Pt 2):F947-56 PMID: 3296786
  108. Roles of urea production, ammonium excretion, and amino acid oxidation in acid-base balance.
    Am J Physiol. 1986 Feb;250(2 Pt 2):F181-8 PMID: 3511732
  109. Complementary distribution of carbamoylphosphate synthetase (ammonia) and glutamine synthetase in rat liver acinus is regulated at a pretranslational level.
    J Histochem Cytochem. 1988 Jul;36(7):751-5 PMID: 2898495
  110. Immunohistochemical localization of glutamate dehydrogenase in rat liver: plasticity of distribution during development and with hormone treatment.
    J Histochem Cytochem. 1988 Jan;36(1):41-7 PMID: 3335769
  111. Developmental and hormonal regulation of carbamoyl-phosphate synthase gene expression in rat liver: evidence for control mechanisms at different levels in the perinatal period.
    Biochim Biophys Acta. 1986 Feb 24;866(1):61-7 PMID: 3947635
  112. Hepatocyte heterogeneity in response to icosanoids. The perivenous scavenger cell hypothesis.
    Eur J Biochem. 1988 Aug 1;175(2):395-403 PMID: 3165342
  113. Mitochondrial metabolism of glutamine and glutamate and its physiological significance.
    Physiol Rev. 1983 Apr;63(2):547-605 PMID: 6132422
  114. The effect of perfusate pH on glutamine metabolism in the isolated perfused rat liver.
    J Biol Chem. 1970 Oct 25;245(20):5491-7 PMID: 5469177
  115. Regulation of the rate of urea synthesis in liver by extracellular pH. A major factor in pH homeostasis in mammals.
    J Biol Chem. 1984 Feb 10;259(3):1552-9 PMID: 6693425
  116. Interorgan glutamine flow in metabolic acidosis.
    Am J Physiol. 1987 Dec;253(6 Pt 2):F1069-76 PMID: 3322041
  117. Hepatic renal interrelations in acid-base regulation.
    Am J Physiol. 1988 Oct;255(4 Pt 2):F807-9 PMID: 3177661
  118. Benzoate stimulates glutamate release from perfused rat liver.
    Biochem J. 1989 Dec 15;264(3):837-43 PMID: 2575901
  119. Role of plasma membrane transport in hepatic glutamine metabolism.
    Eur J Biochem. 1985 Nov 4;152(3):597-603 PMID: 2865140
  120. Metabolism of amino-acids: The synthesis of glutamine from glutamic acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissues.
    Biochem J. 1935 Aug;29(8):1951-69 PMID: 16745865
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2670281
Published
1990-04-15
Pages
281-90
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1131284
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2670281 PMC Full Text View journal details
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