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PMID: 3394957 Published · ppublish English Journal Article

Noradrenergic innervation of developing rat and spiny mouse liver. Its relation to the development of the liver architecture and enzymic zonation.

Anatomy and embryology ·Vol. 178 ·No. 2 ·1988-00-00 ·Pages 175-81

Lamers WH, Høynes KE, Zonneveld D, Moorman AF, Charles R

Abstract

The development of noradrenergic innervation of rat liver was studied with a polyclonal antiserum against noradrenaline. Nerves are first seen in the larger portal vessels at day 1 after birth and reach their final distribution at 5 days after birth i.e. at the same time as the establishment of the acinar architecture and the heterogeneous distribution of NH3-metabolizing enzymes. The latter distribution of nerves is already seen at birth in the liver of the closely related but precocial spiny mouse. This shows that the onset of extrinsic sympathetic innervation is regulated by the developmental stage of the animal rather than by adaptation to extrauterine life. Chemical sympathectomy at birth with 6-hydroxydopamine did not eliminate the developmental appearance of heterogeneous distributions of NH3-metabolizing enzymes.

MeSH Terms
Ammonia/metabolism Animals Animals, Newborn Enzymes/metabolism Immunohistochemistry Liver/growth & development,innervation,metabolism Muridae Norepinephrine/metabolism Rats Rats, Inbred Strains Sympathectomy, Chemical
Chemicals
Enzymes Ammonia Norepinephrine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Lamers W H
Department of Anatomy and Embryology, University of Amsterdam, The Netherlands.
Høynes K E
Zonneveld D
Moorman A F
Charles R
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Article Info
Journal
Anatomy and embryology
Abbr.
Anat Embryol (Berl)
ISSN
0340-2061
DOI
10.1007/BF02463651
Published
1988-00-00
Pages
175-81
Language
English
Region
Germany
NLM ID
7505194
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02463651
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