Organization of the sympathetic innervation in liver tissue from monkey and man.

Cell and tissue research ·Vol. 195 ·No. 3 ·1978-12-29 ·Pages 371-80

Nobin A, Baumgarten HG, Falck B, Ingemansson S, Moghimzadeh E, Rosengren E

Abstract

The sympathetic innervation of the liver of monkey and man has been investigated in a combined fluorescence histochemical, chemical and electron microscopical study. By means of the Falck-Hillarp fluorescence method a dense network of monoamine-containing nerve fibers was visualized in liver tissue of monkey and man. The nerve fibers ran in close contact to both hepatocytes and blood vessels. Chemical quantitations showed high concentrations of noradrenaline in both human and monkey liver. Microspectrofluorometry of the intraneuronal monoamine resulted in spectra characteristic of a catecholamine. For the electron microscopical study the dopamine analogue, 5-hydroxydopamine, was used to "label" the catecholamine terminals in both human and monkey liver. The nerve profiles, identified as catecholamine-containing, were demonstrated in a perivascular location and in close contact to hepatocytes. No synaptic membrane specializations were present between nerve fibers and hepatocytes. The general ultramorphology and intralobular distribution pattern of nerves in the liver of monkey and man were similar. The present results prove the existence of a sympathetic innervation of hepatocytes and blood vessels in the liver of man and monkey.

MeSH Terms

Animals Chemical Phenomena Chemistry Haplorhini Humans Liver/innervation,ultrastructure Macaca mulatta Microscopy, Fluorescence Norepinephrine Spectrometry, Fluorescence Sympathetic Nervous System

Chemicals

Norepinephrine

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Nobin A

Baumgarten H G

Falck B

Ingemansson S

Moghimzadeh E

Rosengren E

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22 references, click to expand

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Article Info

Journal

Cell and tissue research

Abbr.

Cell Tissue Res

ISSN

0302-766X

DOI

10.1007/BF00233883

Published

1978-12-29

Pages

371-80

Language

English

Region

Germany

NLM ID

0417625

Subset

External Links

PubMed source DOI: 10.1007/BF00233883 View journal details

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Organization of the sympathetic innervation in liver tissue from monkey and man.

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