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PMID: 6111022 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The hepatic adrenergic receptors.

Molecular and cellular biochemistry ·Vol. 33 ·No. 1-2 ·1980-12-10 ·Pages 35-48

Schmelck PH, Hanoune J

Abstract

The presence of both alpha- and beta-adrenergic receptors in liver designated the hepatic plasma membrane as a useful tool for the elucidation of the mechanisms by which the hormonal signal is transferred through the membrane via a coupling system to an amplifying entity. This process is well documented for the beta-adrenergic receptor which is linked to adenylate cyclase, whereby it modulates the cyclic AMP level. Much less is known about the alpha-adrenergic receptor. Recently, two factors have contributed to a renewed interest in alpha- and beta-adrenergic receptors in liver: i) The fact that activation of glycogenolysis in isolated liver parenchymal cells by epinephrine may be mediated by either alpha- or beta-adrenergic receptors, depending on the species or on the state of nutrition, and not only by beta-adrenergic receptors as previously thought. ii) The existence of specific adrenergic agonists and antagonists radiolabeled to a high specific activity which has permitted the characterization of adrenergic receptors in terms of nature, number, affinity and regulation. The present review will be devoted to the recent progress made in the physiological, pharmacological and biochemical characterization of alpha- and beta-adrenergic receptors in the liver.

MeSH Terms
Adenylyl Cyclases/metabolism Adrenergic alpha-Agonists/pharmacology Adrenergic alpha-Antagonists/pharmacology Adrenergic beta-Agonists/pharmacology Adrenergic beta-Antagonists/pharmacology Animals Catecholamines/physiology Cell Membrane/physiology Cyclic AMP/metabolism Enzyme Activation Glycogen/metabolism Liver/cytology,physiology Phosphorylase Kinase/metabolism Phosphorylases/metabolism Receptors, Adrenergic/physiology Receptors, Adrenergic, alpha/physiology Receptors, Adrenergic, beta/physiology Species Specificity
Chemicals
Adrenergic alpha-Agonists Adrenergic alpha-Antagonists Adrenergic beta-Agonists Adrenergic beta-Antagonists Catecholamines Receptors, Adrenergic Receptors, Adrenergic, alpha Receptors, Adrenergic, beta Glycogen Cyclic AMP Phosphorylases Phosphorylase Kinase Adenylyl Cyclases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schmelck P H
Hanoune J
References (124)
124 references, click to expand
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF00224570
Published
1980-12-10
Pages
35-48
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00224570 View journal details
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