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PMID: 6870814 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Hormonal stimulation of mitochondrial glutaminase. Effects of vasopressin, angiotensin II, adrenaline and glucagon.

The Biochemical journal ·Vol. 210 ·No. 3 ·1983-03-15 ·Pages 957-60

Corvera S, García-Sáinz JA

Abstract

Adrenaline (through alpha 1-adrenoceptors), vasopressin and angiotensin II stimulate mitochondrial glutaminase activity. This stimulation probably contributes to the ureogenic effect of these hormones. The activity of the enzyme is sensitive to Ca2+ depletion. A role of Ca2+ in hormonal modulation of glutaminase activity is suggested.

MeSH Terms

Angiotensin II/pharmacology Animals Arginine Vasopressin/pharmacology Calcium/pharmacology Epinephrine/pharmacology Female Glucagon/pharmacology Glutaminase/metabolism In Vitro Techniques Mitochondria, Liver/drug effects,enzymology Rats Rats, Inbred Strains Stimulation, Chemical

Chemicals

Angiotensin II Arginine Vasopressin Glucagon Glutaminase Calcium Epinephrine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Corvera S

García-Sáinz J A

References (12)

12 references, click to expand

High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.
J Cell Biol. 1969 Dec;43(3):506-20 PMID: 4900611
The effects of ammonium chloride and bicarbonate on the activity of glutaminase in isolated liver mitochondria.
Biochem J. 1978 Dec 15;176(3):837-44 PMID: 747656
Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.
J Biol Chem. 1980 Mar 10;255(5):1938-44 PMID: 6766458
The hormonal stimulation of ureogenesis in isolated hepatocytes through increases in mitochondrial ATP production.
Arch Biochem Biophys. 1980 Apr 15;201(1):44-55 PMID: 6446885
Stable changes to calcium fluxes in mitochondria isolated from rat livers perfused with alpha-adrenergic agonists and with glucagon.
Biochem J. 1980 May 15;188(2):443-50 PMID: 7396872
The relationship between intramitochondrial N-acetylglutamate and activity of carbamoyl-phosphate synthetase (ammonia). The effect of glucagon.
Eur J Biochem. 1980;107(1):197-205 PMID: 6249585
Ferroactivator and the regulation of gluconeogenesis.
Curr Top Cell Regul. 1981;18:243-54 PMID: 7273843
Alpha 1-adrenoceptor activation stimulates ureogenesis in rat hepatocytes.
Eur J Pharmacol. 1981 Jul 10;72(4):387-90 PMID: 6268427
The stimulation of glutamine hydrolysis in isolated rat liver mitochondria by Mg2+ depletion and hypo-osmotic incubation conditions.
Biochem J. 1981 Jan 15;194(1):35-41 PMID: 6796059
alpha-Adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium.
J Biol Chem. 1982 Jan 10;257(1):190-7 PMID: 6273424
Phosphate-dependent, trifluoperazine-sensitive Ca2+ efflux from rat liver mitochondria. Modulation by a cytosol factor.
FEBS Lett. 1982 May 3;141(1):45-8 PMID: 7084477
Vasopressin and angiotensin II stimulate ureogenesis through increased mitochondrial citrulline production.
Life Sci. 1982 Nov 29;31(22):2493-8 PMID: 7154849

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj2100957

Published

1983-03-15

Pages

957-60

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1154314

Subset

External Links

PubMed source DOI: 10.1042/bj2100957 PMC Full Text View journal details

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Hormonal stimulation of mitochondrial glutaminase. Effects of vasopressin, angiotensin II, adrenaline and glucagon.

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