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PMID: 4054309 Published · ppublish English Journal Article

Channeling of ammonia from glutaminase to carbamoyl-phosphate synthetase in liver mitochondria.

FEBS letters ·Vol. 191 ·No. 2 ·1985-10-28 ·Pages 249-51

Meijer AJ

Abstract

In isolated rat-liver mitochondria the rate of citrulline synthesis from glutamine does not respond to changes in the ammonia concentration in the extramitochondrial fluid. This suggest that ammonia, produced in the mitochondria via glutaminase, is directly channeled to carbamoyl-phosphate synthetase.

MeSH Terms
Ammonia/metabolism Animals Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)/metabolism Citrulline/biosynthesis Glutamine/metabolism Ligases/metabolism Male Mitochondria, Liver/metabolism Rats Rats, Inbred Strains Succinates/metabolism Succinic Acid
Chemicals
Succinates Glutamine Citrulline Ammonia Succinic Acid Ligases Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Meijer A J
Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
0014-5793
DOI
10.1016/0014-5793(85)80018-1
Published
1985-10-28
Pages
249-51
Language
English
Region
England
NLM ID
0155157
Subset
IM
External Links
PubMed source DOI: 10.1016/0014-5793(85)80018-1 View journal details
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