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PMID: 7115327 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Differential effects of starvation on alanine and glutamine transport in isolated rat hepatocytes.

The Biochemical journal ·Vol. 204 ·No. 1 ·1982-04-15 ·Pages 365-8

Hayes MR, McGivan JD

Abstract

At physiological concentrations, alanine transport in hepatocytes from starved rats is faster than in hepatocytes from fed rats. The degree of increase is much less than previously reported for 2-aminoisobutyrate in the same concentration range. Glutamine transport is not stimulated on starvation. This provides evidence that the transport systems for alanine and glutamine in isolated hepatocytes are controlled separately.

MeSH Terms

Alanine/metabolism Animals Biological Transport Cell Separation Glutamine/metabolism In Vitro Techniques Kinetics Liver/metabolism Male Rats Rats, Inbred Strains Starvation/metabolism

Chemicals

Glutamine Alanine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hayes M R

McGivan J D

References (14)

14 references, click to expand

Neutral amino acid transport. Characterization of the A and L systems in isolated rat hepatocytes.
J Biol Chem. 1977 Jan 10;252(1):148-56 PMID: 833114
Direct measurement of active transport systems for alanine in freshly isolated rat liver cells.
Biochem Biophys Res Commun. 1977 Jun 6;76(3):751-7 PMID: 901446
The effect of ammonium chloride and glucagon on the metabolism of glutamine in isolated liver cells from starved rats.
Biochim Biophys Acta. 1978 Sep 21;543(1):16-28 PMID: 708783
Regulation of amino acid transport in the liver. Emergence of a high affinity transport system in isolated hepatocytes from fasting rats.
J Biol Chem. 1979 Jan 25;254(2):401-7 PMID: 83992
Characteristics of the transport of alanine, serine and glutamine across the plasma membrane of isolated rat liver cells.
Biochem J. 1978 Dec 15;176(3):827-36 PMID: 747655
Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses.
Biochem J. 1967 Aug;104(2):497-502 PMID: 6048791
Amino acid transport and rubidium-ion uptake in monolayer cultures of hepatocytes from neonatal rats.
Biochem J. 1981 Sep 15;198(3):475-83 PMID: 6275850
Cysteine as a system-specific substrate for transport system ASC in rat hepatocytes.
Biochem Biophys Res Commun. 1979 May 28;88(2):744-51 PMID: 465067
Hepatic glutamine metabolism under the influence of the portal ammonia concentration in the perfused rat liver.
Eur J Biochem. 1979 Nov 1;101(1):179-84 PMID: 510303
Mechanism of the stimulation of serine and alanine transport into isolated rat liver cells by bicarbonate ions.
Biochem J. 1979 Sep 15;182(3):697-705 PMID: 42391
Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs.
J Biol Chem. 1980 May 10;255(9):4011-9 PMID: 7372663
Plasma-membrane transport of alanine is rate-limiting for its metabolism in rat-liver parenchymal cells.
FEBS Lett. 1980 Oct 6;119(2):271-4 PMID: 7428940
Stimulation of alanine transport and metabolism by dibutyryl cyclic AMP in the hepatocytes from fed rats. Assessment of transport as a potential rate-limiting step for alanine metabolism.
Biochim Biophys Acta. 1981 Jun 22;644(2):295-304 PMID: 6266469
Amino acid transport in isolated hepatocytes after partial hepatectomy in the rat.
Am J Physiol. 1979 Jun;236(6):E594-602 PMID: 443414

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj2040365

Published

1982-04-15

Pages

365-8

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1158355

Subset

External Links

PubMed source DOI: 10.1042/bj2040365 PMC Full Text View journal details

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Differential effects of starvation on alanine and glutamine transport in isolated rat hepatocytes.

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