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PMID: 20010597 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Next-generation synthetic gene networks.

Nature biotechnology ·Vol. 27 ·No. 12 ·2009-12-00 ·Pages 1139-50

Lu TK, Khalil AS, Collins JJ

Abstract

Synthetic biology is focused on the rational construction of biological systems based on engineering principles. During the field's first decade of development, significant progress has been made in designing biological parts and assembling them into genetic circuits to achieve basic functionalities. These circuits have been used to construct proof-of-principle systems with promising results in industrial and medical applications. However, advances in synthetic biology have been limited by a lack of interoperable parts, techniques for dynamically probing biological systems and frameworks for the reliable construction and operation of complex, higher-order networks. As these challenges are addressed, synthetic biologists will be able to construct useful next-generation synthetic gene networks with real-world applications in medicine, biotechnology, bioremediation and bioenergy.

MeSH Terms
DNA/chemical synthesis,economics Forecasting Gene Expression/physiology Genetic Engineering/trends Molecular Biology/trends Signal Transduction/physiology
Chemicals
DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lu Timothy K
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. timlu@mit.edu
Khalil Ahmad S
Collins James J
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Article Info
Journal
Nature biotechnology
Abbr.
Nat Biotechnol
ISSN
1546-1696
DOI
10.1038/nbt.1591
Email
timlu@mit.edu
Published
2009-12-00
Pages
1139-50
Language
English
Region
United States
NLM ID
9604648
PMCID
PMC2796205
Subset
IM
Grants
NIH HHS · DP1 OD003644 · United States
NIH HHS · DP1 OD003644-03 · United States
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1038/nbt.1591 PMC Full Text View journal details
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