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PMID: 19668248 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Microfluidic devices for measuring gene network dynamics in single cells.

Nature reviews. Genetics ·Vol. 10 ·No. 9 ·2009-09-00 ·Pages 628-38

Bennett MR, Hasty J

Abstract

The dynamics governing gene regulation have an important role in determining the phenotype of a cell or organism. From processing extracellular signals to generating internal rhythms, gene networks are central to many time-dependent cellular processes. Recent technological advances now make it possible to track the dynamics of gene networks in single cells under various environmental conditions using microfluidic 'lab-on-a-chip' devices, and researchers are using these new techniques to analyse cellular dynamics and discover regulatory mechanisms. These technologies are expected to yield novel insights and allow the construction of mathematical models that more accurately describe the complex dynamics of gene regulation.

MeSH Terms
Animals Cells/cytology,metabolism Gene Expression Regulation Gene Regulatory Networks/physiology Green Fluorescent Proteins/analysis Humans Kinetics Microfluidic Analytical Techniques/trends Models, Biological
Chemicals
Green Fluorescent Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bennett Matthew R
Department of Biochemistry and Cell Biology and Institute of Biosciences and Bioengineering, Rice University, 6100 Main Street, Houston, Texas 77005-1892, USA. matthew.bennett@rice.edu
Hasty Jeff
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2625
Email
matthew.bennett@rice.edu
Published
2009-09-00
Epub
2009-00-11
Pages
628-38
Language
English
Region
England
NLM ID
100962779
PMCID
PMC2931582
Subset
IM
Grants
NIGMS NIH HHS · R01 GM079333 · United States
NIGMS NIH HHS · R01 GM079333-04 · United States
PHS HHS · GMO79333 · United States
External Links
PubMed source DOI: 10.1038/nrg2625 PMC Full Text View journal details
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