Abstract
The propagation of information through signaling cascades spans a wide range of time scales, including the rapid ligand-receptor interaction and the much slower response of downstream gene expression. To determine which dynamic range dominates a response, we used periodic stimuli to measure the frequency dependence of signal transduction in the osmo-adaptation pathway of Saccharomyces cerevisiae. We applied system identification methods to infer a concise predictive model. We found that the dynamics of the osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis. After large osmotic shocks, an additional, much slower, negative feedback through gene expression allows cells to respond faster to future stimuli.
MeSH Terms
Adaptation, Physiological
Cell Nucleus/metabolism
Feedback, Physiological
Gene Expression Regulation, Fungal
Gene Regulatory Networks
Glycerol/metabolism
Mitogen-Activated Protein Kinases/metabolism
Models, Biological
Osmolar Concentration
Osmotic Pressure
Phosphorylation
Saccharomyces cerevisiae/genetics,metabolism,physiology
Saccharomyces cerevisiae Proteins/metabolism
Signal Transduction
Systems Biology
Chemicals
Saccharomyces cerevisiae Proteins
HOG1 protein, S cerevisiae
Mitogen-Activated Protein Kinases
Glycerol
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mettetal Jerome T
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Muzzey Dale
Gómez-Uribe Carlos
van Oudenaarden Alexander
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