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PMID: 17350994 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Transient dynamics of genetic regulatory networks.

Biophysical journal ·Vol. 92 ·No. 10 ·2007-05-15 ·Pages 3501-12

Bennett MR, Volfson D, Tsimring L, Hasty J

Abstract

We present an approximation scheme for deriving reaction rate equations of genetic regulatory networks. This scheme predicts the timescales of transient dynamics of such networks more accurately than does standard quasi-steady state analysis by introducing prefactors to the ODEs that govern the dynamics of the protein concentrations. These prefactors render the ODE systems slower than their quasi-steady state approximation counterparts. We introduce the method by examining a positive feedback gene regulatory network, and show how the transient dynamics of this network are more accurately modeled when the prefactor is included. Next, we examine the repressilator, a genetic oscillator, and show that the period, amplitude, and bifurcation diagram defining the onset of the oscillations are better estimated by the prefactor method. Finally, we examine the consequences of the method to the dynamics of reduced models of the phage lambda switch, and show that the switching times between the two states is slowed by the presence of the prefactor that arises from protein multimerization and DNA binding.

MeSH Terms
Biological Clocks/physiology Computer Simulation Feedback/physiology Gene Expression Regulation/physiology Kinetics Models, Biological Oscillometry/methods Proteome/metabolism Signal Transduction/physiology Time Factors
Chemicals
Proteome
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bennett Matthew R
Institute for Nonlinear Science, University of California at San Diego, La Jolla, California, USA.
Volfson Dmitri
Tsimring Lev
Hasty Jeff
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
Published
2007-05-15
Epub
2007-00-09
Pages
3501-12
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1853127
Subset
IM
Grants
NIGMS NIH HHS · R01 GM069811 · United States
NIGMS NIH HHS · GM69811-01 · United States
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