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PMID: 18535146 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Tegument proteins of human cytomegalovirus.

Microbiology and molecular biology reviews : MMBR ·Vol. 72 ·No. 2 ·2008-06-00 ·Pages 249-65, table of contents

Kalejta RF

Abstract

Human cytomegalovirus (HCMV) is a common, medically relevant human herpesvirus. The tegument layer of herpesvirus virions lies between the genome-containing capsids and the viral envelope. Proteins within the tegument layer of herpesviruses are released into the cell upon entry when the viral envelope fuses with the cell membrane. These proteins are fully formed and active and control viral entry, gene expression, and immune evasion. Most tegument proteins accumulate to high levels during later stages of infection, when they direct the assembly and egress of progeny virions. Thus, viral tegument proteins play critical roles at the very earliest and very last steps of the HCMV lytic replication cycle. This review summarizes HCMV tegument composition and structure as well as the known and speculated functions of viral tegument proteins. Important directions for future investigation and the challenges that lie ahead are identified and discussed.

MeSH Terms
Cytomegalovirus/genetics,metabolism,physiology Cytomegalovirus Infections/virology Humans Viral Structural Proteins/genetics,metabolism Virion/genetics,metabolism,physiology Virus Replication
Chemicals
Viral Structural Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kalejta Robert F
Institute for Molecular Virology and McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin, USA. rfkalejta@wisc.edu
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1098-5557
DOI
10.1128/MMBR.00040-07
Email
rfkalejta@wisc.edu
Published
2008-06-00
Pages
249-65, table of contents
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC2415745
Subset
IM
Grants
NIAID NIH HHS · R01 AI074984 · United States
NIAID NIH HHS · R56 AI064703 · United States
NIAID NIH HHS · 1R56-AI64703-01A2 · United States
External Links
PubMed source DOI: 10.1128/MMBR.00040-07 PMC Full Text View journal details
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