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PMID: 11161271 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The tegument protein ppUL25 of human cytomegalovirus (CMV) is a major target antigen for the anti-CMV antibody response.

The Journal of general virology ·Vol. 82 ·No. Pt 2 ·2001-02-00 ·Pages 335-338

Lazzarotto T, Varani S, Gabrielli L, Pignatelli S, Landini MP

Abstract

A viral protein of approximately 82 kDa is the only structural protein of human cytomegalovirus (CMV) that is strongly immunogenic during natural infection and the corresponding gene of which is still unknown. In this work, strong evidence is presented that this protein is the product of UL25.

MeSH Terms

Adsorption Antibodies, Viral/immunology Antigens, Viral/chemistry,immunology Blood Donors Cytomegalovirus/chemistry,immunology Female Humans Immune Sera/immunology Immunodominant Epitopes/chemistry,immunology Male Molecular Weight Organ Transplantation Pregnancy Viral Proteins/chemistry,immunology

Chemicals

Antibodies, Viral Antigens, Viral Immune Sera Immunodominant Epitopes UL25 protein, Cytomegalovirus Viral Proteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Lazzarotto Tiziana

Department of Clinical and Experimental Medicine, Division of Microbiology, Laboratory of Virology, University of Bologna, St Orsola General Hospital, Via Massarenti 9, 40138 Bologna, Italy1.

Varani Stefania

Department of Clinical and Experimental Medicine, Division of Microbiology, Laboratory of Virology, University of Bologna, St Orsola General Hospital, Via Massarenti 9, 40138 Bologna, Italy1.

Gabrielli Liliana

Department of Clinical and Experimental Medicine, Division of Microbiology, Laboratory of Virology, University of Bologna, St Orsola General Hospital, Via Massarenti 9, 40138 Bologna, Italy1.

Pignatelli Sara

Department of Clinical and Experimental Medicine, Division of Microbiology, Laboratory of Virology, University of Bologna, St Orsola General Hospital, Via Massarenti 9, 40138 Bologna, Italy1.

Landini Maria Paola

Department of Clinical and Experimental Medicine, Division of Microbiology, Laboratory of Virology, University of Bologna, St Orsola General Hospital, Via Massarenti 9, 40138 Bologna, Italy1.

Article Info

Journal

The Journal of general virology

Abbr.

J Gen Virol

ISSN

0022-1317

DOI

10.1099/0022-1317-82-2-335

Published

2001-02-00

Pages

335-338

Language

English

Region

England

NLM ID

0077340

Subset

IM

External Links

PubMed source DOI: 10.1099/0022-1317-82-2-335 View journal details

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