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PMID: 15450252 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The role of IL-12, IL-23 and IFN-gamma in immunity to viruses.

Cytokine & growth factor reviews ·Vol. 15 ·No. 5 ·2004-10-00 ·Pages 367-77

Novelli F, Casanova JL

Abstract

IL-12, IL-23 and IFN-gamma form a loop and have been thought to play a crucial role against infectious viruses, which are the prototype of "intracellular" pathogens. In the last 10 years, the generation of knock-out (KO) mice for genes that control IL-12/IL-23-dependent IFN-gamma-dependent mediated immunity (STAT1, IFN-gammaR1, IFNgammaR2, IL-12p40 and IL-12Rbeta1) and the identification of patients with spontaneous germline mutations in these genes has led to a re-examination of the role of these cytokines in anti-viral immunity. We here review viral infections in mice and humans with genetic defects in the IL-12/IL-23-IFN-gamma axis. A comparison of the phenotypes observed in KO mice and deficient patients suggests that the human IL-12/IL-23-IFN-gamma axis plays a redundant role in immunity to most viruses, whereas its mouse counterparts play a more important role against several viruses.

MeSH Terms
Animals Humans Interferon-gamma/genetics,immunology Interleukin-12/genetics,immunology Interleukin-23 Interleukin-23 Subunit p19 Interleukins/genetics,immunology Mice Mice, Knockout Virus Diseases/immunology Viruses/immunology
Chemicals
IL23A protein, human Il23a protein, mouse Interleukin-23 Interleukin-23 Subunit p19 Interleukins Interleukin-12 Interferon-gamma
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Novelli Francesco
Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, René Descartes University of Paris, INSERM U550, 156 Rue de Vaugirard, 75015 Paris, France. franco.novelli@unito.it
Casanova Jean-Laurent
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Article Info
Journal
Cytokine & growth factor reviews
Abbr.
Cytokine Growth Factor Rev
ISSN
1359-6101
DOI
10.1016/j.cytogfr.2004.03.009
Email
franco.novelli@unito.it
Published
2004-10-00
Pages
367-77
Language
English
Region
England
NLM ID
9612306
PMCID
PMC7129078
Subset
IM
External Links
PubMed source DOI: 10.1016/j.cytogfr.2004.03.009 PMC Full Text View journal details
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