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PMID: 7636992 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis.

Journal of virology ·Vol. 69 ·No. 9 ·1995-09-00 ·Pages 5469-74

Finke D, Brinckmann UG, ter Meulen V, Liebert UG

Abstract

Measles virus infection of the central nervous system in the murine model of experimental measles virus-induced encephalitis is successfully controlled by virus-specific T-helper lymphocytes. T cells from BALB/c mice that are resistant to measles virus encephalitis proliferate well against measles virus in vitro, and bulk cultures recognize viral nucleocapsid and hemagglutinin as well as fusion proteins. The measles virus-specific T cells secrete large amounts of interleukin 2 (IL-2), gamma interferon (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha) but no IL-4, IL-6, or IL-10, and hence the cytokine pattern is consistent with that of subtype 1 T-helper lymphocytes. In contrast, cells obtained from measles virus-infected susceptible C3H mice recognize measles virus proteins only weakly and secrete little IFN-gamma and TNF-alpha. Treatment of infected mice with anti-TNF-alpha antibodies has no effect on survival or virus clearance from the brain. Upon neutralization of IFN-gamma in vivo, the phenotype of measles virus-specific T-helper cells isolatable from BALB/c mice is reversed from subtype 1 to subtype 2-like. Anti-IFN-gamma antibody-treated BALB/c mice are susceptible to measles virus encephalitis, and viral clearance from the central nervous system is impaired. These results indicate that IFN-gamma plays a significant role in the control of measles virus infection of the central nervous system.

MeSH Terms
Animals Antibodies, Monoclonal Brain/virology CD4 Antigens/immunology CD4-Positive T-Lymphocytes/immunology Disease Susceptibility Interferon-gamma/biosynthesis Interleukin-2/biosynthesis Interleukins/biosynthesis Lymphocyte Depletion Measles virus/immunology,isolation & purification Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred Strains Species Specificity Subacute Sclerosing Panencephalitis/immunology,physiopathology T-Lymphocytes/immunology,virology T-Lymphocytes, Helper-Inducer/immunology Tumor Necrosis Factor-alpha/biosynthesis
Chemicals
Antibodies, Monoclonal CD4 Antigens Interleukin-2 Interleukins Tumor Necrosis Factor-alpha Interferon-gamma
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Finke D
Institut für Virologie und Immunbiologie, Universität Würzburg, Germany.
Brinckmann U G
ter Meulen V
Liebert U G
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.69.9.5469-5474.1995
Published
1995-09-00
Pages
5469-74
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC189396
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.69.9.5469-5474.1995 PMC Full Text View journal details
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