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PMID: 9525580 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immune response to mouse mammary tumor virus in mice lacking the alpha/beta interferon or the gamma interferon receptor.

Journal of virology ·Vol. 72 ·No. 4 ·1998-04-00 ·Pages 2638-46

Maillard I, Launois P, Xenarios I, Louis JA, Acha-Orbea H, Diggelmann H

Abstract

Mouse mammary tumor virus (MMTV) is a retrovirus which induces a strong immune response and a dramatic increase in the number of infected cells through the expression of a superantigen (SAg). Many cytokines are likely to be involved in the interaction between MMTV and the immune system. In particular, alpha/beta interferon (IFN-alpha/beta) and gamma interferon (IFN-gamma) exert many antiviral and immunomodulatory activities and play a critical role in other viral infections. In this study, we have investigated the importance of interferons during MMTV infection by using mice with a disrupted IFN-alpha/beta or IFN-gamma receptor gene. We found that the SAg response to MMTV was not modified in IFN-alpha/betaR(0/0) and IFN-gammaR(0/0) mice. This was true both for the early expansion of B and T cells induced by the SAg and for the deletion of SAg-reactive cells at later stages of the infection. In addition, no increase in the amount of proviral DNA was detected in tissues of IFN-alpha/betaR(0/0) and IFN-gammaR(0/0) mice, suggesting that interferons are not essential antiviral defense mechanisms during MMTV infection. In contrast, IFN-gammaR(0/0) mice had increased amounts of IL-4 mRNA and an altered usage of immunoglobulin isotypes with a reduced frequency of IgG2a- and IgG3-producing cells. This was associated with lower titers of virus-specific antibodies in serum early after infection, although efficient titers were reached later.

MeSH Terms
Animals Antibodies, Viral/immunology Antigens, Viral/immunology Crosses, Genetic DNA, Viral Female Gene Deletion Gene Expression Interferon-gamma/biosynthesis,genetics Interleukin-4/biosynthesis,genetics Male Mammary Tumor Virus, Mouse/immunology Membrane Proteins Mice Mice, Inbred BALB C Polymerase Chain Reaction Proviruses/genetics Receptor, Interferon alpha-beta Receptors, Interferon/genetics,immunology Retroviridae Infections/immunology Superantigens/immunology Time Factors Tumor Virus Infections/immunology
Chemicals
Antibodies, Viral Antigens, Viral DNA, Viral Membrane Proteins Receptors, Interferon Superantigens interferon gamma receptor Receptor, Interferon alpha-beta Interleukin-4 Interferon-gamma
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Maillard I
Institute of Microbiology, University of Lausanne, Switzerland.
Launois P
Xenarios I
Louis J A
Acha-Orbea H
Diggelmann H
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.72.4.2638-2646.1998
Published
1998-04-00
Pages
2638-46
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC109703
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.72.4.2638-2646.1998 PMC Full Text View journal details
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