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PMID: 9032321 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon.

Journal of virology ·Vol. 71 ·No. 3 ·1997-03-00 ·Pages 1906-10

Mo XY, Tripp RA, Sangster MY, Doherty PC

Abstract

Sendai virus is eliminated from the respiratory tract of gamma interferon (IFN-gamma) -/- BALB/c mice with normal kinetics. The level of virus-specific cytotoxic T-lymphocyte (CTL) activity in the cell population recovered by bronchoalveolar lavage is unimpaired, the prevalence of interleukin-4 (IL-4)-producing cells is increased, and the titers of virus-specific immunoglobulins IgG1 and IgG2b are higher in the IFN-gamma -/- mice. The emergence of this T-helper 2 response profile in both lymphoid tissue and the pneumonic lung has no obvious deleterious consequences. Virus clearance is slightly delayed following depletion of the CD4+ subset, with the effect being similar in magnitude for IFN-gamma -/- and +/+ mice. However, the generation of CTL precursors (CTLp) is diminished in the IFN-gamma -/- (but not +/+) mice in the absence of concurrent CD4+ T help. Apparently the clonal expansion of the CTLp population can be promoted either by a cytokine (perhaps IL-2) produced by the IFN-gamma -/- CD4+ T cells or by IFN-gamma made by other cell types in the +/+ mice.

MeSH Terms
Animals Antibodies, Viral/blood Immunoglobulin G/blood Interferon-gamma/genetics,immunology Interleukin-4/analysis Interleukin-5/analysis Mice Mice, Inbred BALB C Pneumonia, Viral/blood,immunology,virology Respirovirus/immunology,isolation & purification Respirovirus Infections/blood,immunology,virology T-Lymphocytes, Cytotoxic/immunology
Chemicals
Antibodies, Viral Immunoglobulin G Interleukin-5 Interleukin-4 Interferon-gamma
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mo X Y
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Tripp R A
Sangster M Y
Doherty P C
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.71.3.1906-1910.1997
Published
1997-03-00
Pages
1906-10
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC191265
Subset
IM
Grants
NIAID NIH HHS · AI 38359 · United States
NCI NIH HHS · CA 21765 · United States
External Links
PubMed source DOI: 10.1128/JVI.71.3.1906-1910.1997 PMC Full Text View journal details
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